IFNB1

IFNB1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AU1
Dynodwyr
Cyfenwau	IFNB1, IFB, IFF, IFNB, IFN-beta, interferon beta 1
Dynodwyr allanol	OMIM: 147640 HomoloGene: 1640 GeneCards: IFNB1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cytokine activity • GO:0005145 cytokine receptor binding • chloramphenicol O-acetyltransferase activity • type I interferon receptor binding Cydrannau o'r gell • extracellular space • extracellular region Prosesau biolegol • positive regulation of peptidyl-serine phosphorylation of STAT protein • blood coagulation • B cell differentiation • cellular response to interferon-beta • regulation of MHC class I biosynthetic process • negative regulation of viral genome replication • natural killer cell activation • B cell activation involved in immune response • positive regulation of apoptotic signaling pathway • cell surface receptor signaling pathway • natural killer cell activation involved in immune response • response to exogenous dsRNA • response to virus • T cell activation involved in immune response • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • defense response • negative regulation of T cell differentiation • positive regulation of innate immune response • cellular response to exogenous dsRNA • negative regulation of T-helper 2 cell cytokine production • defense response to virus • type I interferon signaling pathway • regulation of signaling receptor activity • humoral immune response • B cell proliferation • adaptive immune response • cytokine-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3456	n/a
Ensembl	ENSG00000171855	n/a
UniProt	P01574	n/a
RefSeq (mRNA)	NM_002176	n/a
RefSeq (protein)	NP_002167	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IFNB1 yw IFNB1 a elwir hefyd yn Interferon beta 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9p21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IFNB1.

• IFB
• IFF
• IFNB
• IFN-beta

Llyfryddiaeth

• "PASylation technology improves recombinant interferon-β1b solubility, stability, and biological activity. ". Appl Microbiol Biotechnol. 2017. PMID 27833991.
• "Interferon Beta: From Molecular Level to Therapeutic Effects. ". Int Rev Cell Mol Biol. 2016. PMID 27572132.
• "Impaired Antiviral Stress Granule and IFN-β Enhanceosome Formation Enhances Susceptibility to Influenza Infection in Chronic Obstructive Pulmonary Disease Epithelium. ". Am J Respir Cell Mol Biol. 2016. PMID 26807508.
• "Antitumorigenic effect of interferon-β by inhibition of undifferentiated glioblastoma cells. ". Int J Oncol. 2015. PMID 26397698.
• "Serum levels of IFN-β are associated with days of evolution but not with severity of dengue.". J Med Virol. 2016. PMID 26252251.