IDH2

IDH2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4JA8
Dynodwyr
Cyfenwau	IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH, isocitrate dehydrogenase (NADP(+)) 2, mitochondrial, isocitrate dehydrogenase (NADP(+)) 2, IDH-2
Dynodwyr allanol	OMIM: 147650 HomoloGene: 37590 GeneCards: IDH2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor • oxidoreductase activity • isocitrate dehydrogenase activity • NAD binding • magnesium ion binding • metal ion binding • isocitrate dehydrogenase (NADP+) activity • protein homodimerization activity Cydrannau o'r gell • mitochondrial inner membrane • cytosol • mitochondrial matrix • peroxisome • extracellular exosome • mitocondria Prosesau biolegol • 2-oxoglutarate metabolic process • glyoxylate cycle • isocitrate metabolic process • cylch Krebs • NADP biosynthetic process • negative regulation of glial cell proliferation • negative regulation of glial cell migration • negative regulation of matrix metallopeptidase secretion • mitochondrion organization • carbohydrate metabolic process • NADP metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3418	n/a
Ensembl	ENSG00000182054	n/a
UniProt	P48735	n/a
RefSeq (mRNA)	NM_002168 NM_001289910 NM_001290114	n/a
RefSeq (protein)	NP_001276839 NP_001277043 NP_002159	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IDH2 yw IDH2 a elwir hefyd yn Isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q26.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IDH2.

• IDH
• IDP
• IDHM
• IDPM
• ICD-M
• D2HGA2
• mNADP-IDH

Llyfryddiaeth

• "Frequent IDH2 R172 mutations in undifferentiated and poorly-differentiated sinonasal carcinomas. ". J Pathol. 2017. PMID 28493366.
• "A new functional IDH2 genetic variant is associated with the risk of lung cancer. ". Mol Carcinog. 2017. PMID 27649069.
• "Familial hematological malignancies: new IDH2 mutation. ". Ann Hematol. 2016. PMID 27591990.
• "Downregulation of IDH2 exacerbates the malignant progression of osteosarcoma cells via increased NF-κB and MMP-9 activation. ". Oncol Rep. 2016. PMID 26782630.
• "Photoactivation of Mutant Isocitrate Dehydrogenase 2 Reveals Rapid Cancer-Associated Metabolic and Epigenetic Changes.". J Am Chem Soc. 2016. PMID 26761588.