IDE

IDE
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2G47, 2G48, 2G49, 2G54, 2G56, 2JBU, 2JG4, 2WBY, 2WC0, 2WK3, 2YPU, 3CWW, 3E4A, 3E4Z, 3E50, 3H44, 3HGZ, 3N56, 3N57, 3OFI, 3QZ2, 4DTT, 4DWK, 4GS8, 4GSC, 4GSF, 4IFH, 4IOF, 4LTE, 4M1C, 4Q5Z, 4QIA, 4RAL, 4PES, 4PF7, 4PF9, 4PFC, 4NXO, 4RE9, 5CJO
Dynodwyr
Cyfenwau	IDE, INSULYSIN, insulin degrading enzyme
Dynodwyr allanol	OMIM: 146680 HomoloGene: 3645 GeneCards: IDE
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein homodimerization activity • virus receptor activity • peptide binding • zinc ion binding • amyloid-beta binding • insulin binding • metal ion binding • GO:0001948, GO:0016582 protein binding • peptide hormone binding • GO:0070122 peptidase activity • ATPase activity • beta-endorphin binding • catalytic activity • ubiquitin binding • metalloendopeptidase activity • signaling receptor binding • hydrolase activity • ATP binding • metallopeptidase activity • ubiquitin-dependent protein binding • endopeptidase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • peroxisome • extracellular region • cell surface • cytosolic proteasome complex • mitocondria • cnewyllyn cell • extracellular space • peroxisomal matrix • external side of plasma membrane • basolateral plasma membrane • extracellular exosome Prosesau biolegol • negative regulation of proteolysis • GO:1901047 insulin receptor signaling pathway • insulin metabolic process • bradykinin catabolic process • determination of adult lifespan • protein heterooligomerization • hormone catabolic process • amyloid-beta metabolic process • proteolysis • positive regulation of protein oligomerization • viral entry into host cell • metabolaeth • proteolysis involved in cellular protein catabolic process • ubiquitin recycling • GO:0022415 viral process • protein homooligomerization • protein homotetramerization • insulin catabolic process • protein targeting to peroxisome • GO:0044257 protein catabolic process • GO:1903364 positive regulation of protein catabolic process • amyloid-beta clearance • amyloid-beta clearance by cellular catabolic process • regulation of aerobic respiration • antigen processing and presentation of endogenous peptide antigen via MHC class I • peptide catabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3416	n/a
Ensembl	ENSG00000119912	n/a
UniProt	P14735	n/a
RefSeq (mRNA)	NM_001165946 NM_004969 NM_001322793 NM_001322794 NM_001322795 NM_001322796 NM_001322797	n/a
RefSeq (protein)	NP_001159418 NP_001309722 NP_001309723 NP_001309724 NP_001309725 NP_001309726 NP_004960	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IDE yw IDE a elwir hefyd yn Insulin degrading enzyme (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q23.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IDE.

• INSULYSIN

Llyfryddiaeth

• "Toward Allosterically Increased Catalytic Activity of Insulin-Degrading Enzyme against Amyloid Peptides. ". Biochemistry. 2017. PMID 27982586.
• "Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution. ". PLoS One. 2015. PMID 26186340.
• "Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease. ". J Geriatr Psychiatry Neurol. 2015. PMID 25414272.
• "Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis. ". Int J Neurosci. 2015. PMID 25105907.
• "No major role for insulin-degrading enzyme in antigen presentation by MHC molecules.". PLoS One. 2014. PMID 24516642.