HTRA1

HTRA1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2JOA, 2YTW, 3NUM, 3NWU, 3NZI, 3TJN, 3TJO, 3TJQ
Dynodwyr
Cyfenwau	HTRA1, ARMD7, CARASIL, HtrA, L56, ORF480, PRSS11, CADASIL2, HtrA serine peptidase 1
Dynodwyr allanol	OMIM: 602194 HomoloGene: 31114 GeneCards: HTRA1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • insulin-like growth factor binding • growth factor binding • GO:0070122 peptidase activity • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity • GO:0001948, GO:0016582 protein binding • identical protein binding Cydrannau o'r gell • cytoplasm • cytosol • bilen • GO:0005578 extracellular matrix • Cellbilen • extracellular exosome • extracellular region • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of defense response to virus • chorionic trophoblast cell differentiation • positive regulation of epithelial cell proliferation • placenta development • dentinogenesis • negative regulation of transforming growth factor beta receptor signaling pathway • proteolysis • negative regulation of BMP signaling pathway • regulation of cell growth • extracellular matrix disassembly Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5654	n/a
Ensembl	ENSG00000166033	n/a
UniProt	Q92743	n/a
RefSeq (mRNA)	NM_002775	n/a
RefSeq (protein)	NP_002766	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTRA1 yw HTRA1 a elwir hefyd yn HtrA serine peptidase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q26.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTRA1.

• L56
• HtrA
• ARMD7
• ORF480
• PRSS11
• CARASIL
• CADASIL2

Llyfryddiaeth

• "Distinct molecular mechanisms of HTRA1 mutants in manifesting heterozygotes with CARASIL. ". Neurology. 2016. PMID 27164673.
• "HTRA1 Overexpression Induces the Exudative Form of Age-related Macular Degeneration. ". J Stem Cells. 2015. PMID 27125063.
• "Proteolytic Degradation and Inflammation Play Critical Roles in Polypoidal Choroidal Vasculopathy. ". Am J Pathol. 2017. PMID 28941979.
• "Protective effects of an HTRA1 insertion-deletion variant against age-related macular degeneration in the Chinese populations. ". Lab Invest. 2017. PMID 27841854.
• "The differential role of HTRA1 in HPV-positive and HPV-negative cervical cell line proliferation.". BMC Cancer. 2016. PMID 27809811.