HTR2B

HTR2B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4NC3, 4IB4
Dynodwyr
Cyfenwau	HTR2B, 5-HT(2B), 5-HT2B, 5-HT-2B, 5-hydroxytryptamine receptor 2B
Dynodwyr allanol	OMIM: 601122 HomoloGene: 55492 GeneCards: HTR2B
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • G protein-coupled receptor activity • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • signal transducer activity • G protein-coupled serotonin receptor activity • G-protein alpha-subunit binding • serotonin binding • neurotransmitter receptor activity Cydrannau o'r gell • cytoplasm • integral component of membrane • bilen • Cellbilen • synapse • cell junction • neuron projection • integral component of plasma membrane • nucleoplasm • dendrite Prosesau biolegol • intestine smooth muscle contraction • smooth muscle contraction • G protein-coupled receptor internalization • release of sequestered calcium ion into cytosol • regulation of behavior • positive regulation of endothelial cell proliferation • positive regulation of MAP kinase activity • phosphorylation • GO:0032737 positive regulation of cytokine production • fasogyfyngiad • ERK1 and ERK2 cascade • positive regulation of phosphatidylinositol biosynthetic process • cardiac muscle hypertrophy • heart morphogenesis • cellular calcium ion homeostasis • neural crest cell differentiation • negative regulation of apoptotic process • negative regulation of cell death • activation of phospholipase C activity • protein kinase C signaling • cGMP biosynthetic process • cellular response to temperature stimulus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • heart development • positive regulation of nitric-oxide synthase activity • protein kinase C-activating G protein-coupled receptor signaling pathway • embryonic morphogenesis • serotonin receptor signaling pathway • neural crest cell migration • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • positive regulation of I-kappaB kinase/NF-kappaB signaling • phosphatidylinositol 3-kinase signaling • negative regulation of autophagy • positive regulation of cell division • calcium-mediated signaling • GO:0072468 signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • G protein-coupled receptor signaling pathway • GO:0035737 animal behaviour • cGMP-mediated signaling • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • chemical synaptic transmission Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3357	n/a
Ensembl	ENSG00000135914	n/a
UniProt	P41595	n/a
RefSeq (mRNA)	NM_000867 NM_001320758	n/a
RefSeq (protein)	NP_000858 NP_001307687	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HTR2B yw HTR2B a elwir hefyd yn 5-hydroxytryptamine receptor 2B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q37.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HTR2B.

• 5-HT2B
• 5-HT-2B
• 5-HT(2B)

Llyfryddiaeth

• "Crystal Structure of an LSD-Bound Human Serotonin Receptor. ". Cell. 2017. PMID 28129538.
• "Influence of a HTR2B Stop Codon on Glucagon Homeostasis and Glucose Excursion in Non-Diabetic Men. ". Exp Clin Endocrinol Diabetes. 2016. PMID 27437919.
• "The effects of a HTR2B stop codon and testosterone on energy metabolism and beta cell function among antisocial Finnish males. ". J Psychiatr Res. 2016. PMID 27420381.
• "Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients. ". Oncotarget. 2016. PMID 27013593.
• "Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.". Acta Neuropathol. 2016. PMID 26744351.