HSPA8

HSPA8
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3AGY, 3AGZ, 3ESK, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 4HWI, 3LDQ, 3M3Z, 4H5N, 4H5R, 4H5T, 4H5V, 4H5W, 4KBQ
Dynodwyr
Cyfenwau	HSPA8, HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock protein family A (Hsp70) member 8
Dynodwyr allanol	OMIM: 600816 HomoloGene: 68524 GeneCards: HSPA8
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • heat shock protein binding; • unfolded protein binding; • phosphatidylserine binding; • C3HC4-type RING finger domain binding; • GO:0001948, GO:0016582 protein binding; • MHC class II protein complex binding; • enzyme binding; • G protein-coupled receptor binding; • ATP binding; • ubiquitin protein ligase binding; • ATPase activity; • RNA binding; • cadherin binding; • protein-macromolecule adaptor activity; • protein folding chaperone activity; • chaperone binding; • misfolded protein binding; • clathrin-uncoating ATPase activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • late endosome; • blood microparticle; • bilen; • focal adhesion; • ubiquitin ligase complex; • melanosome; • myelin sheath; • Cellbilen; • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane; • intracellular anatomical structure; • Prp19 complex; • nucleoplasm; • lysosomal membrane; • lysosomal lumen; • nucleolus; • spliceosomal complex; • lumenal side of lysosomal membrane; • extracellular exosome; • cnewyllyn cell; • presynapse; • GO:0005578 extracellular matrix; • extracellular region; • extracellular space; • secretory granule lumen; • ficolin-1-rich granule lumen; • lysosome; • autophagosome; • axon; • dendrite; • terminal bouton; • presynaptic cytosol; • postsynaptic cytosol; • chaperone complex; • ribonucleoprotein complex;
Prosesau biolegol	• chaperone-mediated autophagy; • mRNA splicing, via spliceosome; • late endosomal microautophagy; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • regulation of mRNA stability; • positive regulation of mRNA splicing, via spliceosome; • cellular response to starvation; • mRNA processing; • chaperone-mediated autophagy translocation complex disassembly; • transcription, DNA-templated; • chaperone cofactor-dependent protein refolding; • regulation of cell cycle; • regulation of protein complex stability; • ATP metabolic process; • response to unfolded protein; • clathrin coat disassembly; • protein folding; • protein refolding; • regulation of cellular response to heat; • GO:0022415 viral process; • GO:0045996 negative regulation of transcription, DNA-templated; • GO:0010554 neurotransmitter secretion; • GO:0106159 regulation of protein-containing complex assembly; • negative regulation of supramolecular fiber organization; • regulation of protein import; • RNA splicing; • protein methylation; • neutrophil degranulation; • modulation by host of viral process; • positive regulation by host of viral genome replication; • membrane organization; • protein targeting to lysosome involved in chaperone-mediated autophagy; • axo-dendritic transport; • vesicle-mediated transport; • cytokine-mediated signaling pathway; • cellular response to heat; • Unfolded Protein Response; • slow axonal transport;
	Sources:Amigo / QuickGO
Orthologau
	3312
	n/a
	ENSG00000109971
	n/a
	P11142
	n/a
	NM_006597; NM_153201
	n/a
	NP_006588; NP_694881
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSPA8 yw HSPA8 a elwir hefyd yn Heat shock cognate 71 kDa protein a Heat shock protein family A (Hsp70) member 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q24.1.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSPA8.

LAP1
HSC54
HSC70
HSC71
HSP71
HSP73
LAP-1
NIP71
HEL-33
HSPA10
HEL-S-72p

Llyfryddiaeth[golygu | golygu cod]

"The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70. ". Stem Cells. 2017. PMID 28026090.
"A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of Pluripotency. ". Stem Cell Reports. 2015. PMID 26549849.
"iTRAQ-Based Quantitative Proteomic Analysis Identified HSC71 as a Novel Serum Biomarker for Renal Cell Carcinoma. ". Biomed Res Int. 2015. PMID 26425554.
"Heat stress induces formation of cytoplasmic granules containing HSC70 protein. ". Dokl Biochem Biophys. 2015. PMID 26335814.
"A central role for HSC70 in regulating antigen trafficking and MHC class II presentation.". Mol Immunol. 2015. PMID 25953005.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] HSPA8 - Cronfa NCBI

[1]

[2]