HSD17B8

HSD17B8
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2PD6, 4CQL, 4CQM
Dynodwyr
Cyfenwau	HSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8
Dynodwyr allanol	OMIM: 601417 HomoloGene: 56588 GeneCards: HSD17B8
EC number	1.1.1.239
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • oxidoreductase activity • estradiol 17-beta-dehydrogenase activity • GO:0001948, GO:0016582 protein binding • testosterone dehydrogenase (NAD+) activity • 3-hydroxyacyl-CoA dehydrogenase activity • 3-oxoacyl-[acyl-carrier-protein reductase (NADH) activity] • NADH binding • GO:0050229 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Cydrannau o'r gell • Cellbilen • mitochondrial envelope • bilen • mitocondria • mitochondrial matrix Prosesau biolegol • estrogen biosynthetic process • estrogen metabolic process • androgen metabolic process • fatty acid metabolic process • lipid metabolism • steroid biosynthetic process • fatty acid biosynthetic process • protein heterotetramerization • fatty-acyl-CoA biosynthetic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7923	n/a
Ensembl	ENSG00000204228 ENSG00000228357 ENSG00000225312 ENSG00000232357 ENSG00000112474 ENSG00000228712	n/a
UniProt	Q92506	n/a
RefSeq (mRNA)	NM_014234	n/a
RefSeq (protein)	NP_055049	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSD17B8 yw HSD17B8 a elwir hefyd yn Hydroxysteroid 17-beta dehydrogenase 8 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSD17B8.

• KE6
• FABG
• HKE6
• FABGL
• RING2
• H2-KE6
• SDR30C1
• D6S2245E
• dJ1033B10.9

Llyfryddiaeth

• "Estradiol induces type 8 17beta-hydroxysteroid dehydrogenase expression: crosstalk between estrogen receptor alpha and C/EBPbeta. ". J Endocrinol. 2009. PMID 18852215.
• "Expression of aromatase and 17beta-hydroxysteroid dehydrogenase types 1, 7 and 12 in breast cancer. An immunocytochemical study. ". J Steroid Biochem Mol Biol. 2006. PMID 16930994.
• "Expression in E. coli and tissue distribution of the human homologue of the mouse Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8. ". Mol Cell Biochem. 2008. PMID 17978863.
• "Transcriptional regulation of the human type 8 17beta-hydroxysteroid dehydrogenase gene by C/EBPbeta. ". J Steroid Biochem Mol Biol. 2007. PMID 17583490.
• "Physical mapping 220 kb centromeric of the human MHC and DNA sequence analysis of the 43-kb segment including the RING1, HKE6, and HKE4 genes.". Genomics. 1997. PMID 9205114.