HSD17B4

HSD17B4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IKT, 1S9C, 1ZBQ
Dynodwyr
Cyfenwau	HSD17B4, DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, hydroxysteroid (17-beta) dehydrogenase 4, hydroxysteroid 17-beta dehydrogenase 4
Dynodwyr allanol	OMIM: 601860 HomoloGene: 358 GeneCards: HSD17B4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein homodimerization activity • isomerase activity • lyase activity • 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity • oxidoreductase activity • long-chain-enoyl-CoA hydratase activity • signaling receptor binding • 17-beta-hydroxysteroid dehydrogenase (NAD+) activity • 3-hydroxyacyl-CoA dehydrogenase activity Cydrannau o'r gell • bilen • peroxisome • peroxisomal membrane • peroxisomal matrix • mitocondria • cytosol Prosesau biolegol • estrogen metabolic process • androgen metabolic process • lipid metabolism • alpha-linolenic acid metabolic process • very long-chain fatty acid metabolic process • Sertoli cell development • fatty acid metabolic process • very long-chain fatty-acyl-CoA metabolic process • fatty acid beta-oxidation using acyl-CoA oxidase • osteoblast differentiation • medium-chain fatty-acyl-CoA metabolic process • fatty acid beta-oxidation • bile acid biosynthetic process • protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3295	n/a
Ensembl	ENSG00000133835	n/a
UniProt	P51659	n/a
RefSeq (mRNA)	NM_001292028 NM_000414 NM_001199291 NM_001199292 NM_001292027	n/a
RefSeq (protein)	NP_000405 NP_001186220 NP_001186221 NP_001278956 NP_001278957 NP_001361426 NP_001361427 NP_001361428 NP_001361429 NP_001361430 NP_001361431 NP_001361432	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSD17B4 yw HSD17B4 a elwir hefyd yn Hydroxysteroid 17-beta dehydrogenase 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q23.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSD17B4.

• DBP
• MFE-2
• MPF-2
• PRLTS1
• SDR8C1

Llyfryddiaeth

• "A homozygous missense variant in HSD17B4 identified in a consanguineous Chinese Han family with type II Perrault syndrome. ". BMC Med Genet. 2017. PMID 28830375.
• "Acetylation targets HSD17B4 for degradation via the CMA pathway in response to estrone. ". Autophagy. 2017. PMID 28296597.
• "Pathological complete response of HER2-positive breast cancer to trastuzumab and chemotherapy can be predicted by HSD17B4 methylation. ". Oncotarget. 2017. PMID 28186977.
• "NF-κB increased expression of 17β-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol. ". Mol Cell Endocrinol. 2015. PMID 25448063.
• "On the molecular basis of D-bifunctional protein deficiency type III.". PLoS One. 2013. PMID 23308274.