HSD17B10

HSD17B10
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1SO8, 1U7T, 2O23
Dynodwyr
Cyfenwau	HSD17B10, 17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, hydroxysteroid (17-beta) dehydrogenase 10, hydroxysteroid 17-beta dehydrogenase 10, HSD10MD
Dynodwyr allanol	OMIM: 300256 HomoloGene: 68403 GeneCards: HSD17B10
EC number	1.1.1.51
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • testosterone dehydrogenase [NAD(P) activity] • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity • GO:0001948, GO:0016582 protein binding • oxidoreductase activity • cholate 7-alpha-dehydrogenase activity • RNA binding • 3-hydroxyacyl-CoA dehydrogenase activity • tRNA binding • dihydrotestosterone 17-beta-dehydrogenase activity Cydrannau o'r gell • cytoplasm • Cellbilen • mitochondrial matrix • mitocondria • mitochondrial ribonuclease P complex Prosesau biolegol • lipid metabolism • branched-chain amino acid catabolic process • mitochondrial tRNA processing • mitochondrial tRNA methylation • tRNA processing • mitochondrion organization • protein homotetramerization • mitochondrial tRNA 5'-end processing • mitochondrial tRNA 3'-end processing Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3028	n/a
Ensembl	ENSG00000072506	n/a
UniProt	Q99714	n/a
RefSeq (mRNA)	NM_004493 NM_001037811	n/a
RefSeq (protein)	NP_001032900 NP_004484	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSD17B10 yw HSD17B10 a elwir hefyd yn Hydroxysteroid 17-beta dehydrogenase 10 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom X dynol, band Xp11.22.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSD17B10.

• ABAD
• CAMR
• ERAB
• HCD2
• MHBD
• HADH2
• MRPP2
• MRX17
• MRX31
• SCHAD
• MRXS10
• SDR5C1
• HSD10MD
• 17b-HSD10
• DUPXp11.22

Llyfryddiaeth

• "Novel patient missense mutations in the HSD17B10 gene affect dehydrogenase and mitochondrial tRNA modification functions of the encoded protein. ". Biochim Biophys Acta. 2017. PMID 28888424.
• "17β-Hydroxysteroid dehydrogenase type 10 predicts survival of patients with colorectal cancer and affects mitochondrial DNA content. ". Cancer Lett. 2016. PMID 26884257.
• "Molecular insights into HSD10 disease: impact of SDR5C1 mutations on the human mitochondrial RNase P complex. ". Nucleic Acids Res. 2015. PMID 25925575.
• "Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death. ". BMC Cancer. 2015. PMID 25879199.
• "Mitochondrial energy failure in HSD10 disease is due to defective mtDNA transcript processing.". Mitochondrion. 2015. PMID 25575635.