HSD11B1

HSD11B1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4P38, 1XU9, 2BEL, 2ILT, 2IRW, 2RBE, 3BYZ, 3BZU, 3CH6, 3CZR, 3D3E, 3D4N, 3D5Q, 3EY4, 3FCO, 3FRJ, 3H6K, 3HFG, 3OQ1, 3PDJ, 3QQP, 3TFQ, 4BB5, 4BB6, 4C7J, 4C7K, 4HFR, 4HX5, 4IJU, 4IJV, 4IJW, 4K1L, 4YYZ, 1XU7
Dynodwyr
Cyfenwau	HSD11B1, 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, hydroxysteroid (11-beta) dehydrogenase 1, hydroxysteroid 11-beta dehydrogenase 1
Dynodwyr allanol	OMIM: 600713 HomoloGene: 68471 GeneCards: HSD11B1
EC number	1.1.1.146
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • 11-beta-hydroxysteroid dehydrogenase (NADP+) activity • oxidoreductase activity • 11-beta-hydroxysteroid dehydrogenase [NAD(P) activity] • steroid binding Cydrannau o'r gell • integral component of membrane • endoplasmic reticulum membrane • Reticwlwm endoplasmig • bilen Prosesau biolegol • glucocorticoid biosynthetic process • lung development • lipid metabolism • steroid metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3290	n/a
Ensembl	ENSG00000117594	n/a
UniProt	P28845	n/a
RefSeq (mRNA)	NM_181755 NM_001206741 NM_005525	n/a
RefSeq (protein)	NP_001193670 NP_005516 NP_861420 NP_001193670.1 NP_005516.1 NP_861420.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HSD11B1 yw HSD11B1 a elwir hefyd yn Hydroxysteroid 11-beta dehydrogenase 1 isoform A a Corticosteroid 11-beta-dehydrogenase isozyme 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 1, band 1q32.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HSD11B1.

• HDL
• 11-DH
• HSD11
• HSD11B
• HSD11L
• CORTRD2
• SDR26C1
• 11-beta-HSD1

Llyfryddiaeth

• "11β-Hydroxysteroid Dehydrogenase Type 1 in Obese Subjects With Type 2 Diabetes Mellitus. ". Am J Med Sci. 2017. PMID 29078846.
• "The cortisol-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 in skeletal muscle in the pathogenesis of the metabolic syndrome. ". J Steroid Biochem Mol Biol. 2017. PMID 28765040.
• "11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids. ". Biochem Biophys Res Commun. 2017. PMID 28698139.
• "Associations between a polymorphism in the hydroxysteroid (11-beta) dehydrogenase 1 gene, neuroticism and postpartum depression. ". J Affect Disord. 2017. PMID 27721188.
• "Genetic Variation in the 11β-hydroxysteroid-dehydrogenase 1 Gene Determines NAFLD and Visceral Obesity.". J Clin Endocrinol Metab. 2016. PMID 27715400.