HRAS

HRAS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 121P, 1AA9, 1AGP, 1BKD, 1CLU, 1CRP, 1CRQ, 1CRR, 1CTQ, 1GNP, 1GNQ, 1GNR, 1HE8, 1IAQ, 1IOZ, 1JAH, 1JAI, 1K8R, 1LF0, 1LF5, 1LFD, 1NVU, 1NVV, 1NVW, 1NVX, 1P2S, 1P2T, 1P2U, 1P2V, 1PLJ, 1PLK, 1PLL, 1Q21, 1QRA, 1RVD, 1WQ1, 1XCM, 1XD2, 1XJ0, 1ZVQ, 1ZW6, 221P, 2C5L, 2CE2, 2CL0, 2CL6, 2CL7, 2CLC, 2CLD, 2EVW, 2LCF, 2LWI, 2Q21, 2QUZ, 2RGA, 2RGB, 2RGC, 2RGD, 2RGE, 2RGG, 2UZI, 2VH5, 2X1V, 3DDC, 3I3S, 3K8Y, 3K9L, 3K9N, 3KKM, 3KKN, 3KUD, 3L8Y, 3L8Z, 3LBH, 3LBI, 3LBN, 3LO5, 3OIU, 3OIV, 3OIW, 3RRY, 3RRZ, 3RS0, 3RS2, 3RS3, 3RS4, 3RS5, 3RS7, 3RSL, 3RSO, 421P, 4DLR, 4DLS, 4DLT, 4DLU, 4DLV, 4DLW, 4DLX, 4DLY, 4DLZ, 4EFL, 4EFM, 4EFN, 4G0N, 4G3X, 4K81, 4Q21, 521P, 5P21, 621P, 6Q21, 721P, 821P, 4L9S, 4L9W, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2N42, 2N46, 4XVQ, 4XVR, 4RSG, 5B30
Dynodwyr
Cyfenwau	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, RASH1, p21ras, Harvey rat sarcoma viral oncogene homolog, HRas proto-oncogene, GTPase, RASK2
Dynodwyr allanol	OMIM: 190020 HomoloGene: 55890 GeneCards: HRAS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • protein C-terminus binding • GO:0001948, GO:0016582 protein binding • GO:0006184 GTPase activity • GTP binding • GDP binding Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • intracellular membrane-bounded organelle • bilen • Golgi membrane • Cellbilen • perinuclear region of cytoplasm • cnewyllyn cell • glutamatergic synapse Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • defense response to protozoan • positive regulation of protein phosphorylation • regulation of long-term neuronal synaptic plasticity • endocytosis • positive regulation of MAP kinase activity • positive regulation of miRNA metabolic process • positive regulation of epithelial cell proliferation • positive regulation of ruffle assembly • mitotic cell cycle checkpoint signaling • positive regulation of cell migration • ephrin receptor signaling pathway • positive regulation of wound healing • positive regulation of Ras protein signal transduction • positive regulation of interferon-gamma production • stimulatory C-type lectin receptor signaling pathway • positive regulation of JNK cascade • negative regulation of gene expression • MAPK cascade • intrinsic apoptotic signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • chemotaxis • cell surface receptor signaling pathway • GO:1901313 positive regulation of gene expression • GO:0034259 negative regulation of GTPase activity • positive regulation of cell population proliferation • positive regulation of ERK1 and ERK2 cascade • animal organ morphogenesis • T-helper 1 type immune response • Ras protein signal transduction • cell population proliferation • T cell receptor signaling pathway • positive regulation of actin cytoskeleton reorganization • positive regulation of MAPK cascade • negative regulation of cell population proliferation • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • GO:0097285 apoptotic process • small GTPase mediated signal transduction • cellular senescence • response to isolation stress • cellular response to gamma radiation • positive regulation of DNA replication • positive regulation of phospholipase C activity • protein heterooligomerization • positive regulation of protein targeting to membrane • regulation of neurotransmitter receptor localization to postsynaptic specialization membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3265	n/a
Ensembl	ENSG00000276536 ENSG00000174775	n/a
UniProt	P01112	n/a
RefSeq (mRNA)	NM_001130442 NM_005343 NM_176795 NM_001318054	n/a
RefSeq (protein)	NP_001123914 NP_001304983 NP_005334 NP_789765	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HRAS yw HRAS a elwir hefyd yn HRas proto-oncogene, GTPase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11p15.5.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HRAS.

• CTLO
• HAMSV
• HRAS1
• RASH1
• p21ras
• C-H-RAS
• H-RASIDX
• C-BAS/HAS
• C-HA-RAS1

Llyfryddiaeth

• "Phenotypic spectrum of Costello syndrome individuals harboring the rare HRAS mutation p.Gly13Asp. ". Am J Med Genet A. 2017. PMID 28371260.
• "Retinal dystrophy in two boys with Costello syndrome due to the HRAS p.Gly13Cys mutation. ". Am J Med Genet A. 2017. PMID 28337834.
• "Local tumour progression after percutaneous ablation of colorectal liver metastases according to RAS mutation status. ". Br J Surg. 2017. PMID 28240361.
• "RASopathies Are Associated With Delayed Puberty; Are They Associated With Precocious Puberty Too?". Pediatrics. 2016. PMID 27940666.
• "The Splicing Efficiency of Activating HRAS Mutations Can Determine Costello Syndrome Phenotype and Frequency in Cancer.". PLoS Genet. 2016. PMID 27195699.