HPN

HPN
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1O5E, 1O5F, 1P57, 1Z8G, 3T2N, 5CE1
Dynodwyr
Cyfenwau	HPN, TMPRSS1, hepsin
Dynodwyr allanol	OMIM: 142440 HomoloGene: 20498 GeneCards: HPN
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • serine-type exopeptidase activity • calcium-activated potassium channel activity • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • serine-type peptidase activity • hydrolase activity • serine-type endopeptidase activity Cydrannau o'r gell • integral component of membrane • nuclear membrane • endoplasmic reticulum membrane • bilen • cell-cell junction • integral component of plasma membrane • cell surface • neuronal cell body • apical plasma membrane • extracellular exosome • Cellbilen Prosesau biolegol • positive regulation of hepatocyte proliferation • positive regulation of plasminogen activation • response to thyroid hormone • negative regulation of apoptotic process • proteolysis • detection of mechanical stimulus involved in sensory perception of sound • positive regulation of thyroid hormone generation • positive regulation of cell growth • GO:1901313 positive regulation of gene expression • pilomotor reflex • cochlea morphogenesis • potassium ion transmembrane transport • regulation of cell shape • negative regulation of epithelial cell proliferation • basement membrane disassembly • negative regulation of epithelial to mesenchymal transition • hepatocyte growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3249	n/a
Ensembl	ENSG00000105707	n/a
UniProt	P05981	n/a
RefSeq (mRNA)	NM_002151 NM_182983 NM_001375441 NM_001384133	n/a
RefSeq (protein)	NP_002142 NP_892028 NP_001362370 NP_001371062	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HPN yw HPN a elwir hefyd yn Hepsin (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HPN.

• TMPRSS1

Llyfryddiaeth

• "Concurrent Hepsin overexpression and adenomatous polyposis coli deletion causes invasive prostate carcinoma in mice. ". Prostate. 2015. PMID 26139199.
• "Variants in the HEPSIN gene are associated with susceptibility to prostate cancer. ". Prostate Cancer Prostatic Dis. 2012. PMID 22665141.
• "Allosteric antibody inhibition of human hepsin protease. ". Biochem J. 2012. PMID 22132769.
• "Clinical and biological significance of hepsin overexpression in breast cancer. ". J Investig Med. 2011. PMID 21383634.
• "Isolation, purification, and study of properties of recombinant hepsin from Escherichia coli.". Biochemistry (Mosc). 2010. PMID 20673210.