HPGDS

HPGDS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IYH, 1IYI, 1V40, 2CVD, 2VCQ, 2VCW, 2VCX, 2VCZ, 2VD0, 2VD1, 3EE2, 3KXO, 3VI5, 3VI7, 4EC0, 4EDY, 4EDZ, 4EE0, 5AIS, 5AIV, 5AIX
Dynodwyr
Cyfenwau	HPGDS, GSTS, GSTS1-1, PGD2, PGDS, GSTS1, hematopoietic prostaglandin D synthase
Dynodwyr allanol	OMIM: 602598 HomoloGene: 113741 GeneCards: HPGDS
EC number	2.5.1.18
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • calcium ion binding • protein homodimerization activity • isomerase activity • metal ion binding • prostaglandin-D synthase activity • GO:0001948, GO:0016582 protein binding • magnesium ion binding • glutathione transferase activity Cydrannau o'r gell • cytoplasm • cytosol Prosesau biolegol • prostaglandin metabolic process • locomotory behavior • lipid metabolism • cyclooxygenase pathway • fatty acid metabolic process • fatty acid biosynthetic process • prostaglandin biosynthetic process • glutathione derivative biosynthetic process • GO:0072468 signal transduction • negative regulation of male germ cell proliferation • glutathione metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	27306	n/a
Ensembl	ENSG00000163106	n/a
UniProt	O60760	n/a
RefSeq (mRNA)	NM_014485	n/a
RefSeq (protein)	NP_055300	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HPGDS yw HPGDS a elwir hefyd yn Hematopoietic prostaglandin D synthase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 4, band 4q22.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HPGDS.

• GSTS
• PGD2
• PGDS
• GSTS1
• GSTS1-1

Llyfryddiaeth

• "Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. ". Prostaglandins Other Lipid Mediat. 2012. PMID 21821144.
• "UV resonance Raman studies on the activation mechanism of human hematopoietic prostaglandin D(2) synthase by a divalent cation, Mg(2+). ". J Inorg Biochem. 2010. PMID 20074808.
• "Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase. ". Anal Biochem. 2016. PMID 27485270.
• "Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle. ". BMC Complement Altern Med. 2014. PMID 24996417.
• "Human hematopoietic prostaglandin D synthase inhibitor complex structures.". J Biochem. 2012. PMID 22418579.