HOXA9

HOXA9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1PUF
Dynodwyr
Cyfenwau	HOXA9, ABD-B, HOX1, HOX1.7, HOX1G, homeobox A9
Dynodwyr allanol	OMIM: 142956 HomoloGene: 7766 GeneCards: HOXA9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • GO:0001948, GO:0016582 protein binding • enzyme binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding Cydrannau o'r gell • cnewyllyn cell • transcription regulator complex • cytoplasm Prosesau biolegol • GO:0009373 regulation of transcription, DNA-templated • endothelial cell activation • transcription, DNA-templated • multicellular organism development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of myeloid cell differentiation • spermatogenesis • single fertilization • male gonad development • anterior/posterior pattern specification • proximal/distal pattern formation • regulation of gene expression • mammary gland development • embryonic forelimb morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • embryonic skeletal system development • uterus development • definitive hemopoiesis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3205	n/a
Ensembl	ENSG00000078399	n/a
UniProt	P31269	n/a
RefSeq (mRNA)	NM_152739 NM_002142	n/a
RefSeq (protein)	NP_689952	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HOXA9 yw HOXA9 a elwir hefyd yn Homeobox A9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 7, band 7p15.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HOXA9.

• HOX1
• ABD-B
• HOX1G
• HOX1.7

Llyfryddiaeth

• "Advanced Glycation End-Products Downregulate HoxA9EC through Activation of Nuclear Factor Kappa B by Reciprocal Interaction. ". J Vasc Res. 2017. PMID 28723696.
• "An Epigenomic Approach to Improving Response to Neoadjuvant Cisplatin Chemotherapy in Bladder Cancer. ". Biomolecules. 2016. PMID 27598218.
• "HOXA9 is Underexpressed in Cervical Cancer Cells and its Restoration Decreases Proliferation, Migration and Expression of Epithelial-to-Mesenchymal Transition Genes. ". Asian Pac J Cancer Prev. 2016. PMID 27039722.
• "Role of HOXA9 in leukemia: dysregulation, cofactors and essential targets. ". Oncogene. 2016. PMID 26028034.
• "A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.". Oncotarget. 2015. PMID 25762636.