HOMER1

HOMER1
Dynodwyr
Cyfenwau	HOMER1, HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1, homer scaffolding protein 1, homer scaffold protein 1
Dynodwyr allanol	OMIM: 604798 HomoloGene: 3155 GeneCards: HOMER1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transmembrane transporter binding • signaling adaptor activity • GO:0001948, GO:0016582 protein binding • G protein-coupled glutamate receptor binding Cydrannau o'r gell • cytoplasm • postsynaptic membrane • bilen • GO:0097483, GO:0097481 postsynaptic density • Cellbilen • apical part of cell • synapse • axon • cell junction • Z disc • neuron projection • costamere • postsynapse • cytosol • neuron spine • cell projection • dendritic spine • dendrite • glutamatergic synapse • postsynaptic cytosol Prosesau biolegol • phospholipase C-activating G protein-coupled glutamate receptor signaling pathway • positive regulation of signal transduction • behavioral response to cocaine • skeletal muscle contraction • regulation of calcium ion import • response to calcium ion • chemical homeostasis within a tissue • skeletal muscle fiber development • positive regulation of calcium ion transport • chemical synaptic transmission • regulation of cation channel activity • regulation of store-operated calcium entry • protein tetramerization • regulation of synaptic transmission, glutamatergic • regulation of dendritic spine maintenance • G protein-coupled glutamate receptor signaling pathway • regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9456	n/a
Ensembl	ENSG00000152413	n/a
UniProt	Q86YM7	n/a
RefSeq (mRNA)	NM_004272 NM_001277077 NM_001277078	n/a
RefSeq (protein)	NP_001264006 NP_001264007 NP_004263	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HOMER1 yw HOMER1 a elwir hefyd yn Homer scaffolding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q14.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HOMER1.

• HOMER
• SYN47
• Ves-1
• HOMER1A
• HOMER1B
• HOMER1C

Llyfryddiaeth

• "Association of common genetic variants of HOMER1 gene with levodopa adverse effects in Parkinson's disease patients. ". Pharmacogenomics J. 2014. PMID 24126708.
• "The uncoupling of synaptic protein homer 1c from target proteins activates store-operated calcium entry in a neurotransmitter-like manner in human neuroblastoma cells. ". Dokl Biol Sci. 2013. PMID 23821062.
• "Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. ". Oncol Rep. 2016. PMID 26718835.
• "Signaling pathways regulating Homer1a expression: implications for antidepressant therapy. ". Biol Chem. 2016. PMID 26641965.
• "Identification of Homer1 as a potential prognostic marker for intrahepatic cholangiocarcinoma.". Asian Pac J Cancer Prev. 2014. PMID 24815486.