HNRNPK

HNRNPK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1J5K, 1KHM, 1ZZI, 1ZZJ, 1ZZK
Dynodwyr
Cyfenwau	HNRNPK, CSBP, HNRPK, TUNP, AUKS, heterogeneous nuclear ribonucleoprotein K
Dynodwyr allanol	OMIM: 600712 HomoloGene: 81909 GeneCards: HNRNPK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • nucleic acid binding • DNA binding • single-stranded DNA binding • RNA binding • cadherin binding • protein domain specific binding • identical protein binding Cydrannau o'r gell • cytoplasm • bilen • focal adhesion • cnewyllyn cell • catalytic step 2 spliceosome • cell projection • extracellular exosome • podosome • spliceosomal complex • cell junction • GO:0005578 extracellular matrix • nucleoplasm • cytoplasmic stress granule Prosesau biolegol • positive regulation of receptor-mediated endocytosis • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of mRNA splicing, via spliceosome • regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • GO:0022415 viral process • GO:0033168, GO:0036404, GO:1902360 RNA processing • mRNA processing • regulation of low-density lipoprotein particle clearance • mRNA splicing, via spliceosome • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of apoptotic process • RNA splicing • transcription by RNA polymerase II • RNA metabolic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3190	n/a
Ensembl	ENSG00000165119	n/a
UniProt	P61978	n/a
RefSeq (mRNA)	NM_002140 NM_031262 NM_031263 NM_001318186 NM_001318187 NM_001318188	n/a
RefSeq (protein)	NP_001305115 NP_001305116 NP_001305117 NP_002131 NP_112552 NP_112553	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HNRNPK yw HNRNPK a elwir hefyd yn Heterogeneous nuclear ribonucleoprotein K (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q21.32.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HNRNPK.

• AUKS
• CSBP
• TUNP
• HNRPK

Llyfryddiaeth

• "Nujiangexathone A, a novel compound from Garcinia nujiangensis, suppresses cervical cancer growth by targeting hnRNPK. ". Cancer Lett. 2016. PMID 27424288.
• "Heterogeneous nuclear ribonucleoprotein K is overexpressed and associated with poor prognosis in gastric cancer. ". Oncol Rep. 2016. PMID 27278897.
• "HnRNP K contributes to drug resistance in acute myeloid leukemia through the regulation of autophagy. ". Exp Hematol. 2016. PMID 27155326.
• "Aberrant hnRNP K expression: All roads lead to cancer. ". Cell Cycle. 2016. PMID 27049467.
• "A de novo frameshift in HNRNPK causing a Kabuki-like syndrome with nodular heterotopia.". Clin Genet. 2016. PMID 26954065.