HMOX1

HMOX1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1N3U, 1N45, 1NI6, 1OYK, 1OYL, 1OZE, 1OZL, 1OZR, 1OZW, 1S13, 1S8C, 1T5P, 1TWN, 1TWR, 1XJZ, 1XK0, 1XK1, 1XK2, 1XK3, 3CZY, 3HOK, 3K4F, 3TGM, 4WD4, 5BTQ
Dynodwyr
Cyfenwau	HMOX1, HMOX1D, HO-1, HSP32, bK286B10, heme oxygenase 1
Dynodwyr allanol	OMIM: 141250 HomoloGene: 31075 GeneCards: HMOX1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• phospholipase D activity; • protein homodimerization activity; • heme oxygenase (decyclizing) activity; • metal ion binding; • signal transducer activity; • heme binding; • GO:0001948, GO:0016582 protein binding; • enzyme binding; • oxidoreductase activity;
Cydrannau o'r gell	• cytosol; • endoplasmic reticulum membrane; • bilen; • intracellular membrane-bounded organelle; • nucleolus; • Reticwlwm endoplasmig; • caveola; • perinuclear region of cytoplasm; • cnewyllyn cell; • extracellular space;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • GO:0097285 apoptotic process; • cellular iron ion homeostasis; • negative regulation of smooth muscle cell proliferation; • cellular response to heat; • GO:0007243 intracellular signal transduction; • negative regulation of mast cell cytokine production; • response to hypoxia; • Ysgarthu; • low-density lipoprotein particle clearance; • regulation of transcription from RNA polymerase II promoter in response to oxidative stress; • small GTPase mediated signal transduction; • negative regulation of DNA binding; • response to nicotine; • iron ion homeostasis; • marwolaeth celloedd; • heme oxidation; • negative regulation of mast cell degranulation; • cellular response to cadmium ion; • regulation of angiogenesis; • negative regulation of muscle cell apoptotic process; • GO:0001306 response to oxidative stress; • negative regulation of DNA-binding transcription factor activity; • cellular response to nutrient; • positive regulation of angiogenesis; • response to estrogen; • wound healing involved in inflammatory response; • regulation of blood pressure; • heme catabolic process; • erythrocyte homeostasis; • regulation of DNA-binding transcription factor activity; • cellular response to arsenic-containing substance; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • angiogenesis; • intrinsic apoptotic signaling pathway in response to DNA damage; • endothelial cell proliferation; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • smooth muscle hyperplasia; • protein homooligomerization; • negative regulation of leukocyte migration; • cellular response to hypoxia; • response to hydrogen peroxide; • negative regulation of cell population proliferation; • heme metabolic process; • positive regulation of smooth muscle cell proliferation; • regulation of transcription from RNA polymerase II promoter in response to iron; • positive regulation of apoptotic process; • cellular response to cisplatin; • positive regulation of macroautophagy; • negative regulation of vascular associated smooth muscle cell proliferation; • negative regulation of epithelial cell apoptotic process; • liver regeneration; • negative regulation of macroautophagy;
	Sources:Amigo / QuickGO
Orthologau
	3162
	n/a
	ENSG00000100292
	n/a
	P09601
	n/a
	NM_002133
	n/a
	NP_002124
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HMOX1 yw HMOX1 a elwir hefyd yn Heme oxygenase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 22, band 22q12.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HMOX1.

HO-1
HSP32
HMOX1D
bK286B10

Llyfryddiaeth[golygu | golygu cod]

"Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia. ". Hypertension. 2018. PMID 29203625.
"Repeat polymorphisms in the Homo sapiens heme oxygenase-1 gene in diabetic and idiopathic gastroparesis. ". PLoS One. 2017. PMID 29161307.
"Acetylation is essential for nuclear heme oxygenase-1-enhanced tumor growth and invasiveness. ". Oncogene. 2017. PMID 28846111.
"Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation. ". PLoS One. 2017. PMID 28806787.
"Potential role of heme metabolism in the inducible expression of heme oxygenase-1.". Biochim Biophys Acta. 2017. PMID 28347842.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] HMOX1 - Cronfa NCBI

[1]

[2]