HLA-E

HLA-E
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3CII, 1KPR, 1KTL, 1MHE, 2ESV, 3AM8, 3BZE, 3BZF, 3CDG
Dynodwyr
Cyfenwau	HLA-E, EA1.2, EA2.1, HLA-6.2, MHC, QA1, major histocompatibility complex, class I, E
Dynodwyr allanol	OMIM: 143010 HomoloGene: 134018 GeneCards: HLA-E
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • beta-2-microglobulin binding • MHC class I protein binding • signaling receptor binding • natural killer cell lectin-like receptor binding • peptide antigen binding • T cell receptor binding Cydrannau o'r gell • integral component of membrane • phagocytic vesicle membrane • early endosome membrane • bilen • MHC class Ib protein complex • Golgi membrane • Cellbilen • cell surface • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • extracellular exosome • recycling endosome membrane Prosesau biolegol • antigen processing and presentation • adaptive immune response • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • CD8-positive, alpha-beta T cell activation • interferon-gamma-mediated signaling pathway • immune system process • antigen processing and presentation of peptide antigen via MHC class I • positive regulation of T cell mediated cytotoxicity • positive regulation of TRAIL production • positive regulation of interleukin-4 production • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • protection from natural killer cell mediated cytotoxicity • positive regulation of interleukin-13 production • type I interferon signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of natural killer cell mediated immunity • positive regulation of natural killer cell mediated immunity • regulation of immune response • positive regulation of tumor necrosis factor production • innate immune response • positive regulation of CD8-positive, alpha-beta T cell proliferation • antigen processing and presentation of endogenous peptide antigen via MHC class Ib Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3133	n/a
Ensembl	ENSG00000204592 ENSG00000225201 ENSG00000236632 ENSG00000230254 ENSG00000206493 ENSG00000233904 ENSG00000229252	n/a
UniProt	P13747	n/a
RefSeq (mRNA)	NM_005516	n/a
RefSeq (protein)	NP_005507	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-E yw HLA-E a elwir hefyd yn Major histocompatibility complex, class I, E (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6p22.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-E.

• QA1
• HLA-6.2

Llyfryddiaeth

• "The prognostic benefit of tumour-infiltrating Natural Killer cells in endometrial cancer is dependent on concurrent overexpression of Human Leucocyte Antigen-E in the tumour microenvironment. ". Eur J Cancer. 2017. PMID 29059634.
• "HLA-E regulatory and coding region variability and haplotypes in a Brazilian population sample. ". Mol Immunol. 2017. PMID 28946074.
• "Association of high HLA-E expression during acute cellular rejection and numbers of HLA class I leader peptide mismatches with reduced renal allograft survival. ". Immunobiology. 2017. PMID 27871782.
• "HLA-E allelic genotype correlates with HLA-E plasma levels and predicts early progression in chronic lymphocytic leukemia. ". Cancer. 2017. PMID 27859015.
• "Is HLA-E a possible genetic marker relevant for natural conception?". Am J Reprod Immunol. 2016. PMID 27714943.