HLA-C

HLA-C
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3BZF,%%s4NT6,%%s1EFX,%%s1IM9, 1QQD
Dynodwyr
Cyfenwau	HLA-C, D6S204, HLA-JY3, HLC-C, PSORS1, major histocompatibility complex, class I, C, MHC
Dynodwyr allanol	OMIM: 142840 HomoloGene: 133080 GeneCards: HLA-C
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptide antigen binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • phagocytic vesicle membrane • Golgi apparatus • early endosome membrane • bilen • Golgi membrane • Cellbilen • cell surface • Reticwlwm endoplasmig • MHC class I protein complex • ER to Golgi transport vesicle membrane • integral component of lumenal side of endoplasmic reticulum membrane • extracellular exosome • secretory granule membrane • recycling endosome membrane Prosesau biolegol • antigen processing and presentation • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • immune system process • interferon-gamma-mediated signaling pathway • antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent • type I interferon signaling pathway • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • regulation of immune response • GO:0022415 viral process • neutrophil degranulation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3107	n/a
Ensembl	ENSG00000204525 ENSG00000233841 ENSG00000228299 ENSG00000225691 ENSG00000206435 ENSG00000237022 ENSG00000206452	n/a
UniProt	P10321	n/a
RefSeq (mRNA)	NM_002117 NM_001243042	n/a
RefSeq (protein)	NP_001229971 NP_002108	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HLA-C yw HLA-C a elwir hefyd yn HLA class I histocompatibility antigen, Cw-5 alpha chain, HLA class I histocompatibility antigen, Cw-17 alpha chain, HLA class I histocompatibility antigen, Cw-16 alpha chain a HLA class I histocompatibility antigen, Cw-18 alpha chain (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 6, band 6p21.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HLA-C.

• MHC
• HLAC
• HLC-C
• D6S204
• PSORS1
• HLA-JY3

Llyfryddiaeth

• "Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity. ". J Virol. 2018. PMID 29070683.
• "Association of Natural Killer Cell Ligand Polymorphism HLA-C Asn80Lys With the Development of Anti-SSA/Ro-Associated Congenital Heart Block. ". Arthritis Rheumatol. 2017. PMID 29045069.
• "The molecular basis for peptide repertoire selection in the human leucocyte antigen (HLA) C*06:02 molecule. ". J Biol Chem. 2017. PMID 28855257.
• "Genome-wide association study of nevirapine hypersensitivity in a sub-Saharan African HIV-infected population. ". J Antimicrob Chemother. 2017. PMID 28062682.
• "Variation of maternal KIR and fetal HLA-C genes in reproductive failure: too early for clinical intervention.". Reprod Biomed Online. 2016. PMID 27751789.