HIP1R

HIP1R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1R0D
Dynodwyr
Cyfenwau	HIP1R, HIP12, HIP3, ILWEQ, huntingtin interacting protein 1 related
Dynodwyr allanol	OMIM: 605613 HomoloGene: 78348 GeneCards: HIP1R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • actin binding • GO:0001948, GO:0016582 protein binding • phospholipid binding • phosphatidylinositol binding • phosphatidylinositol-4,5-bisphosphate binding • phosphatidylinositol-3,4,5-trisphosphate binding • SH3 domain binding • clathrin binding • clathrin light chain binding • clathrin adaptor activity • protein homodimerization activity • phosphatidylinositol-3,4-bisphosphate binding • protein heterodimerization activity • actin filament binding • phosphatidylinositol-3,5-bisphosphate binding • identical protein binding Cydrannau o'r gell • perinuclear region of cytoplasm • clathrin-coated pit • Cytosgerbwd • clathrin-coated vesicle membrane • intracellular membrane-bounded organelle • endomembrane system • bilen • GO:0016023 cytoplasmic vesicle • clathrin-coated vesicle • cytoplasm • mitocondria • cytosol • cell cortex • GO:0097483, GO:0097481 postsynaptic density • apical plasma membrane • ruffle membrane • dendrite cytoplasm • neuronal cell body • dendritic spine • synaptic membrane • AP-2 adaptor complex • actin cortical patch Prosesau biolegol • endocytosis • receptor-mediated endocytosis • GO:0097285 apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of endocytosis • negative regulation of actin filament polymerization • positive regulation of protein binding • regulation of actin cytoskeleton organization • negative regulation of Arp2/3 complex-mediated actin nucleation • positive regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of epidermal growth factor receptor signaling pathway • clathrin coat assembly • protein stabilization • digestive system development • regulation of gastric acid secretion • membrane organization • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • positive regulation of clathrin coat assembly • positive regulation of platelet-derived growth factor receptor-beta signaling pathway • regulation of clathrin-dependent endocytosis • actin filament organization • positive regulation of receptor-mediated endocytosis Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9026	n/a
Ensembl	ENSG00000130787	n/a
UniProt	O75146	n/a
RefSeq (mRNA)	NM_001303097 NM_001303099 NM_003959	n/a
RefSeq (protein)	NP_001290026 NP_001290028 NP_003950	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HIP1R yw HIP1R a elwir hefyd yn Huntingtin-interacting protein 1-related protein (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 12, band 12q24.31.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HIP1R.

• HIP3
• HIP12
• ILWEQ

Llyfryddiaeth

• "Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1). ". J Hum Genet. 1998. PMID 9852681.
• "The single nucleotide polymorphism Rs12817488 is associated with Parkinson's disease in the Chinese population. ". J Clin Neurosci. 2015. PMID 25818163.
• "Low HIP1R mRNA and protein expression are associated with worse survival in diffuse large B-cell lymphoma patients treated with R-CHOP. ". Exp Mol Pathol. 2015. PMID 26341140.
• "Huntingtin-interacting protein 1-related is required for accurate congression and segregation of chromosomes. ". BMB Rep. 2010. PMID 21189155.
• "Analysis of a variable number tandem repeat polymorphism in the huntingtin interacting protein-1 related gene for anticipation in bipolar affective disorder.". Prog Neuropsychopharmacol Biol Psychiatry. 2004. PMID 15588756.