HINT1

HINT1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AV5, 1KPA, 1KPB, 1KPC, 1KPE, 1KPF, 3TW2, 4EQE, 4EQG, 4EQH, 4ZKL, 4ZKV, 5I2E, 5I2F
Dynodwyr
Cyfenwau	HINT1, HINT, NMAN, PKCI-1, PRKCNH1, histidine triad nucleotide binding protein 1
Dynodwyr allanol	OMIM: 601314 HomoloGene: 3904 GeneCards: HINT1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • catalytic activity • hydrolase activity • protein kinase C binding Cydrannau o'r gell • histone deacetylase complex • Cellbilen • extracellular exosome • Cytosgerbwd • cnewyllyn cell • cytoplasm • cytosol Prosesau biolegol • purine ribonucleotide catabolic process • positive regulation of calcium-mediated signaling • GO:0009373 regulation of transcription, DNA-templated • transcription, DNA-templated • intrinsic apoptotic signaling pathway by p53 class mediator • GO:0072468 signal transduction • GO:0097285 apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3094	n/a
Ensembl	ENSG00000169567	n/a
UniProt	P49773	n/a
RefSeq (mRNA)	NM_005340	n/a
RefSeq (protein)	NP_005331	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HINT1 yw HINT1 a elwir hefyd yn Histidine triad nucleotide binding protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HINT1.

• HINT
• NMAN
• PKCI-1
• PRKCNH1

Llyfryddiaeth

• "Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain. ". Biochem Biophys Res Commun. 2017. PMID 28739258.
• "Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1). ". Biochemistry. 2017. PMID 28691797.
• "Axonal neuropathy with neuromyotonia: there is a HINT. ". Brain. 2017. PMID 28007994.
• "Crystallographic studies of the complex of human HINT1 protein with a non-hydrolyzable analog of Ap4A. ". Int J Biol Macromol. 2016. PMID 26905466.
• "Absence of HINT1 mutations in a UK and Spanish cohort of patients with inherited neuropathies.". J Neurol. 2015. PMID 26194197.