HIF1A Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1H2K , 1H2L , 1H2M , 1L3E , 1L8C , 1LM8 , 1LQB , 2ILM , 3HQR , 3HQU , 4AJY , 4H6J
Dynodwyr Cyfenwau HIF1A Dynodwyr allanol OMIM: 603348 HomoloGene: 1171 GeneCards: HIF1A Ontoleg y genyn Gweithrediad moleciwlaidd • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • histone deacetylase binding • transcription factor binding • enzyme binding • GO:0001948, GO:0016582 protein binding • histone acetyltransferase binding • protein kinase binding • Hsp90 protein binding • sequence-specific DNA binding • DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • ubiquitin protein ligase binding • protein heterodimerization activity • E-box binding • p53 binding • protein domain specific binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding Cydrannau o'r gell • cytoplasm • cytosol • cnewyllyn cell • nuclear speck • motile cilium • transcription regulator complex • RNA polymerase II transcription regulator complex • axon cytoplasm • nucleoplasm • nuclear body • GO:0009327 protein-containing complex Prosesau biolegol • GO:1904089 negative regulation of neuron apoptotic process • B-1 B cell homeostasis • regulation of transforming growth factor beta2 production • muscle cell cellular homeostasis • outflow tract morphogenesis • negative regulation of ossification • heart looping • negative regulation of TOR signaling • blood vessel development • hemoglobin biosynthetic process • angiogenesis • positive regulation of chemokine-mediated signaling pathway • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of hormone biosynthetic process • negative regulation of mesenchymal cell apoptotic process • regulation of aerobic respiration • positive regulation of neuroblast proliferation • dopaminergic neuron differentiation • lactate metabolic process • GO:0009373 regulation of transcription, DNA-templated • blood vessel morphogenesis • positive regulation of erythrocyte differentiation • glucose homeostasis • vascular endothelial growth factor production • regulation of thymocyte apoptotic process • positive regulation of epithelial cell migration • negative regulation of thymocyte apoptotic process • transcription, DNA-templated • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • axonal transport of mitochondrion • positive regulation of macroautophagy • cartilage development • positive regulation of nitric-oxide synthase activity • regulation of transcription from RNA polymerase II promoter in response to hypoxia • lactation • negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway • positive regulation of pri-miRNA transcription by RNA polymerase II • digestive tract morphogenesis • cell differentiation • neural fold elevation formation • positive regulation of autophagy • retina vasculature development in camera-type eye • collagen metabolic process • embryonic placenta development • negative regulation of apoptotic process • positive regulation of angiogenesis • regulation of glycolytic process • epithelial to mesenchymal transition • cerebral cortex development • regulation of gene expression • positive regulation of chemokine production • intestinal epithelial cell maturation • GO:0048552 regulation of catalytic activity • positive regulation of autophagy of mitochondrion • cardiac ventricle morphogenesis • response to muscle activity • epithelial cell differentiation involved in mammary gland alveolus development • visual learning • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of bone mineralization • negative regulation of growth • response to hypoxia • positive regulation of endothelial cell proliferation • regulation of transcription from RNA polymerase II promoter in response to oxidative stress • iris morphogenesis • mRNA transcription by RNA polymerase II • hypoxia-inducible factor-1alpha signaling pathway • vasculature development • regulation of cell population proliferation • neural crest cell migration • embryonic hemopoiesis • connective tissue replacement involved in inflammatory response wound healing • positive regulation of transcription from RNA polymerase II promoter in response to hypoxia • negative regulation of reactive oxygen species metabolic process • positive regulation of vascular endothelial growth factor production • elastin metabolic process • positive regulation of glycolytic process • oxygen homeostasis • GO:0072468 signal transduction • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • cellular iron ion homeostasis • camera-type eye morphogenesis • cellular response to hypoxia • cellular response to interleukin-1 • transcription by RNA polymerase II • protein deubiquitination • post-translational protein modification • response to iron ion • negative regulation of gene expression • positive regulation of blood vessel endothelial cell migration • GO:1901313 positive regulation of gene expression • cytokine-mediated signaling pathway • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • protein ubiquitination Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[ 1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn HIF1A yw HIF1A a elwir hefyd yn Hypoxia-inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor), isoform CRA_a a Hypoxia-inducible factor 1, alpha subunit (Basic helix-loop-helix transcription factor), isoform CRA_b (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q23.2.[ 2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HIF1A.
HIF1
MOP1
PASD8
HIF-1A
bHLHe78
HIF-1alpha
HIF1-ALPHA
HIF-1-alpha
"HIF1α-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment. ". Anticancer Res . 2017. PMID 28739726 . "Expression of hypoxia inducible factor 1 alpha and its clinical significance in esophageal carcinoma: A meta-analysis. ". Tumour Biol . 2017. PMID 28671053 . "Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells. ". Biochem Biophys Res Commun . 2018. PMID 29113799 . "Hypoxia in Combination With Muscle Contraction Improves Insulin Action and Glucose Metabolism in Human Skeletal Muscle via the HIF-1α Pathway. ". Diabetes . 2017. PMID 28811274 . "Low temperature plasma induces angiogenic growth factor via up-regulating hypoxia-inducible factor 1α in human dermal fibroblasts. ". Arch Biochem Biophys . 2017. PMID 28750820 . 
