HHEX

HHEX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2E1O
Dynodwyr
Cyfenwau	HHEX, HEX, HMPH, HOX11L-PEN, PRH, PRHX, hematopoietically expressed homeobox
Dynodwyr allanol	OMIM: 604420 HomoloGene: 31110 GeneCards: HHEX
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • sequence-specific DNA binding • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • HMG box domain binding • transcription factor binding • chromatin binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • eukaryotic initiation factor 4E binding • TBP-class protein binding • DNA binding, bending • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific Cydrannau o'r gell • cytoplasm • protein-DNA complex • cnewyllyn cell Prosesau biolegol • Notch signaling pathway • myeloid leukocyte differentiation • endoderm development • DNA conformation change • GO:0009373 regulation of transcription, DNA-templated • primary lung bud formation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • multicellular organism growth • embryonic organ development • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of vascular endothelial growth factor receptor signaling pathway • interkinetic nuclear migration • negative regulation of transcription by competitive promoter binding • hepatocyte differentiation • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • Wnt signaling pathway • tissue morphogenesis • mRNA export from nucleus • transcription, DNA-templated • embryonic heart tube development • vasculogenesis • morphogenesis of an epithelium • poly(A)+ mRNA export from nucleus • positive regulation of Wnt signaling pathway • forebrain morphogenesis • multicellular organism development • hepatoblast differentiation • thyroid gland development • common bile duct development • regulation of cell population proliferation • protein localization to nucleus • gall bladder development • negative regulation of angiogenesis • pancreas development • animal organ morphogenesis • B cell differentiation • hepatic duct development • liver development • negative regulation of transcription by transcription factor localization • forebrain development • cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • primitive streak formation • anterior/posterior pattern specification • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • GO:0072468 signal transduction • response to peptide hormone • response to wounding • cell differentiation • hemopoiesis • regulation of leukocyte proliferation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3087	n/a
Ensembl	ENSG00000152804	n/a
UniProt	Q03014	n/a
RefSeq (mRNA)	NM_002729	n/a
RefSeq (protein)	NP_002720	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HHEX yw HHEX a elwir hefyd yn Hematopoietically expressed homeobox (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q23.33.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HHEX.

• HEX
• PRH
• HMPH
• PRHX
• HOX11L-PEN

Llyfryddiaeth

• "HHEX: A Crosstalker between HCMV Infection and Proliferation of VSMCs. ". Front Cell Infect Microbiol. 2016. PMID 27965937.
• "Screening of HHEX Mutations in Chinese Children with Thyroid Dysgenesis. ". J Clin Res Pediatr Endocrinol. 2016. PMID 26757609.
• "The HHEX gene is not related to congenital heart disease in 296 Chinese patients. ". World J Pediatr. 2013. PMID 23929257.
• "Hematopoietically-expressed homeobox gene three widely-evaluated polymorphisms and risk for diabetes: a meta-analysis. ". PLoS One. 2012. PMID 23166797.
• "Dasatinib inhibits leukaemic cell survival by decreasing PRH/Hhex phosphorylation resulting in increased repression of VEGF signalling genes.". Leuk Res. 2012. PMID 22874537.