HGS

HGS
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX
Dynodwyr
Cyfenwau	HGS, HRS, hepatocyte growth factor-regulated tyrosine kinase substrate
Dynodwyr allanol	OMIM: 604375 HomoloGene: 37954 GeneCards: HGS
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • metal ion binding • GO:0001948, GO:0016582 protein binding • ubiquitin-like protein ligase binding Cydrannau o'r gell • endosome • early endosome membrane • multivesicular body membrane • intracellular membrane-bounded organelle • bilen • early endosome • extracellular exosome • cytoplasm • lysosome • cytosol • ESCRT-0 complex Prosesau biolegol • protein localization to membrane • protein targeting to lysosome • negative regulation of epidermal growth factor receptor signaling pathway • membrane invagination • multivesicular body assembly • endosomal transport • GO:1901313 positive regulation of gene expression • GO:1903362 regulation of protein catabolic process • protein transport • regulation of MAP kinase activity • positive regulation of exosomal secretion • intracellular protein transport • GO:0072468 signal transduction • negative regulation of cell population proliferation • negative regulation of receptor signaling pathway via JAK-STAT • macroautophagy • protein deubiquitination • membrane organization • GO:0015915 transport • negative regulation of platelet-derived growth factor receptor signaling pathway • negative regulation of angiogenesis • negative regulation of vascular endothelial growth factor receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9146	n/a
Ensembl	ENSG00000185359	n/a
UniProt	O14964	n/a
RefSeq (mRNA)	NM_004712	n/a
RefSeq (protein)	NP_004703	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HGS yw HGS a elwir hefyd yn Hepatocyte growth factor-regulated tyrosine kinase substrate (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 17, band 17q25.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HGS.

• HRS

Llyfryddiaeth

• "Clinical value of plasma hepatocyte growth factor measurement for the diagnosis of periampullary cancer and prognosis after pancreaticoduodenectomy. ". J Surg Oncol. 2010. PMID 20812348.
• "ESCRT-I function is required for Tyrp1 transport from early endosomes to the melanosome limiting membrane. ". Traffic. 2009. PMID 19624486.
• "A kinome siRNA screen identifies HGS as a potential target for liver cancers with oncogenic mutations in CTNNB1. ". BMC Cancer. 2015. PMID 26715116.
• "An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. ". Cell Rep. 2012. PMID 22832105.
• "Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway.". Virology. 2012. PMID 22138215.