HEY1

HEY1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2DB7
Dynodwyr
Cyfenwau	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1, hes related family bHLH transcription factor with YRPW motif 1, NERP2
Dynodwyr allanol	OMIM: 602953 HomoloGene: 7756 GeneCards: HEY1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • microsatellite binding • DNA binding • protein dimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • transcription factor binding • GO:0000983 RNA polymerase II general transcription initiation factor activity • GO:0001948, GO:0016582 protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • GO:0001106 transcription corepressor activity • sequence-specific DNA binding • sequence-specific double-stranded DNA binding Cydrannau o'r gell • cytoplasm • nucleoplasm • cnewyllyn cell Prosesau biolegol • dorsal aorta morphogenesis • pulmonary valve morphogenesis • negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation • GO:0009373 regulation of transcription, DNA-templated • heart trabecula formation • regulation of vasculogenesis • cardiac septum morphogenesis • ventricular septum morphogenesis • labyrinthine layer blood vessel development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • endocardial cushion morphogenesis • multicellular organism development • atrioventricular valve formation • arterial endothelial cell differentiation • cellular response to glucocorticoid stimulus • umbilical cord morphogenesis • negative regulation of transcription regulatory region DNA binding • angiogenesis • GO:0045996 negative regulation of transcription, DNA-templated • cardiac ventricle morphogenesis • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • negative regulation of Notch signaling pathway • cardiac epithelial to mesenchymal transition • Notch signaling involved in heart development • Notch signaling pathway • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated • blood vessel development • heart development • cell differentiation • regulation of neurogenesis • GO:1901313 positive regulation of gene expression • negative regulation of biomineral tissue development • anterior/posterior pattern specification • negative regulation of neuron differentiation • circulatory system development Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	23462	n/a
Ensembl	ENSG00000164683	n/a
UniProt	Q9Y5J3	n/a
RefSeq (mRNA)	NM_012258 NM_001040708 NM_001282851	n/a
RefSeq (protein)	NP_001035798 NP_001269780 NP_036390	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HEY1 yw HEY1 a elwir hefyd yn Hes related family bHLH transcription factor with YRPW motif 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q21.13.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HEY1.

• CHF2
• OAF1
• HERP2
• HESR1
• HRT-1
• hHRT1
• BHLHb31

Llyfryddiaeth

• "Identification and characterization of the Hesr1/Hey1 as a candidate trans-acting factor on gene expression through the 3' non-coding polymorphic region of the human dopamine transporter (DAT1) gene. ". J Biochem. 2005. PMID 15749835.
• "Hey1, a mediator of notch signaling, is an androgen receptor corepressor. ". Mol Cell Biol. 2005. PMID 15684393.
• "Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone. ". Bone. 2010. PMID 19857617.
• "A role for the transcription factor HEY1 in glioblastoma. ". J Cell Mol Med. 2009. PMID 18363832.
• "Protective effects of transcription factor HESR1 on retinal vasculature.". Microvasc Res. 2006. PMID 17028039.