HDAC7

HDAC7
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3C0Y, 3C0Z, 3C10, 3ZNR, 3ZNS
Dynodwyr
Cyfenwau	HDAC7, HD7A, HDAC7A, HD7, histone deacetylase 7
Dynodwyr allanol	OMIM: 606542 HomoloGene: 9124 GeneCards: HDAC7
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • metal ion binding • GO:0001106 transcription corepressor activity • protein kinase binding • 14-3-3 protein binding • hydrolase activity • protein kinase C binding • chromatin binding • histone deacetylase activity • NAD-dependent histone deacetylase activity (H3-K14 specific) • GO:0001948, GO:0016582 protein binding • SUMO transferase activity Cydrannau o'r gell • nucleoplasm • cytoplasm • cnewyllyn cell • histone deacetylase complex • cytosol Prosesau biolegol • transcription, DNA-templated • negative regulation of NIK/NF-kappaB signaling • positive regulation of cell migration involved in sprouting angiogenesis • cell-cell junction assembly • vasculogenesis • GO:1901227 negative regulation of transcription by RNA polymerase II • histone H3 deacetylation • negative regulation of osteoblast differentiation • negative regulation of interleukin-2 production • GO:0009373 regulation of transcription, DNA-templated • histone deacetylation • GO:0045996 negative regulation of transcription, DNA-templated • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • protein sumoylation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	51564	n/a
Ensembl	ENSG00000061273	n/a
UniProt	Q8WUI4	n/a
RefSeq (mRNA)	NM_001098416 NM_001308090 NM_015401 NM_016596 NM_001368046	n/a
RefSeq (protein)	NP_001091886 NP_001295019 NP_056216 NP_001354975	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HDAC7 yw HDAC7 a elwir hefyd yn Histone deacetylase 7 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q13.11.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HDAC7.

• HD7
• HD7A
• HDAC7A

Llyfryddiaeth

• "The role of histone deacetylase 7 (HDAC7) in cancer cell proliferation: regulation on c-Myc. ". J Mol Med (Berl). 2011. PMID 21120446.
• "[RNA interference of HDAC7 expression in hepatocellular carcinoma]. ". Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2010. PMID 20693714.
• "HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells. ". Diabetologia. 2017. PMID 27796421.
• "Detection of proneural/mesenchymal marker expression in glioblastoma: temporospatial dynamics and association with chromatin-modifying gene expression. ". J Neurooncol. 2015. PMID 26272600.
• "HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages.". PLoS Genet. 2013. PMID 23696748.