HDAC6 Dynodwyr Cyfenwau HDAC6 Dynodwyr allanol OMIM: 300272 HomoloGene: 31353 GeneCards: HDAC6 Ontoleg y genyn Gweithrediad moleciwlaidd • histone deacetylase binding • misfolded protein binding • metal ion binding • enzyme binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • beta-catenin binding • zinc ion binding • polyubiquitin modification-dependent protein binding • GO:0001948, GO:0016582 protein binding • tau protein binding • dynein complex binding • Hsp90 protein binding • histone deacetylase activity • microtubule binding • alpha-tubulin binding • ubiquitin binding • beta-tubulin binding • actin binding • hydrolase activity • ubiquitin protein ligase binding • tubulin deacetylase activity • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • protein deacetylase activity • acetylspermidine deacetylase activity Cydrannau o'r gell • cytosol • perinuclear region of cytoplasm • caveola • microtubule • cnewyllyn cell • multivesicular body • cell projection • microtubule associated complex • aggresome • dynein complex • histone deacetylase complex • perikaryon • axon • inclusion body • dendrite • cell leading edge • cytoplasmic microtubule • cell body • neuron projection • nucleoplasm • cytoplasm • GO:0009327 protein-containing complex Prosesau biolegol • Hsp90 deacetylation • protein quality control for misfolded or incompletely synthesized proteins • response to organic substance • cellular response to topologically incorrect protein • tubulin deacetylation • regulation of establishment of protein localization • ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway • response to growth factor • intracellular protein transport • aggresome assembly • negative regulation of proteolysis • histone H3 deacetylation • positive regulation of signal transduction • peptidyl-lysine deacetylation • response to misfolded protein • GO:0009373 regulation of transcription, DNA-templated • regulation of protein stability • ubiquitin-dependent protein catabolic process • mitochondrion localization • positive regulation of epithelial cell migration • regulation of fat cell differentiation • transcription, DNA-templated • regulation of autophagy of mitochondrion • polyubiquitinated misfolded protein transport • response to toxic substance • positive regulation of hydrogen peroxide-mediated programmed cell death • regulation of microtubule-based movement • regulation of signaling receptor activity • protein polyubiquitination • protein deacetylation • negative regulation of hydrogen peroxide metabolic process • regulation of autophagy • GO:2001216 negative regulation of oxidoreductase activity • regulation of androgen receptor signaling pathway • GO:0045996 negative regulation of transcription, DNA-templated • cellular response to misfolded protein • positive regulation of chaperone-mediated protein complex assembly • regulation of gene expression, epigenetic • negative regulation of protein-containing complex disassembly • autophagy • negative regulation of microtubule depolymerization • lysosome localization • histone deacetylation • cellular response to hydrogen peroxide • collateral sprouting • dendritic spine morphogenesis • cilium assembly • regulation of macroautophagy • parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization • positive regulation of mitophagy in response to mitochondrial depolarization • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization • positive regulation of protein oligomerization • GO:0043624 protein-containing complex disassembly • positive regulation of peptidyl-serine phosphorylation • polyamine deacetylation • spermidine deacetylation Sources:Amigo / QuickGO
Orthologau Species Bod dynol Llygoden Entrez Ensembl UniProt RefSeq (mRNA) RefSeq (protein) Lleoliad (UCSC) n/a n/a PubMed search[1] n/a Wicidata
Protein sy'n cael ei godio yn y corff dynol gan y genyn HDAC6 yw HDAC6 a elwir hefyd yn Histone deacetylase 6 (Saesneg). Segment o DNA yw'r genyn , sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom X dynol, band Xp11.23.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HDAC6.
"HDAC6 promotes cell proliferation and confers resistance to temozolomide in glioblastoma. ". Cancer Lett . 2016. PMID 27267806 . "HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. ". Oncol Rep . 2016. PMID 27221381 . "ACY-1215 accelerates vemurafenib induced cell death of BRAF-mutant melanoma cells via induction of ER stress and inhibition of ERK activation. ". Oncol Rep . 2017. PMID 28035401 . "Cellular defence or viral assist: the dilemma of HDAC6. ". J Gen Virol . 2017. PMID 27959772 . "Inhibition of HDAC6 Protein Enhances Bortezomib-induced Apoptosis in Head and Neck Squamous Cell Carcinoma (HNSCC) by Reducing Autophagy. ". J Biol Chem . 2016. PMID 27369083 . 
