HCN4

HCN4
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP
Dynodwyr
Cyfenwau	HCN4, SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4, BRGDA8, EIG18
Dynodwyr allanol	OMIM: 605206 HomoloGene: 3997 GeneCards: HCN4
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• nucleotide binding; • potassium channel activity; • cAMP binding; • sodium channel activity; • voltage-gated ion channel activity; • ion channel activity; • intracellular cAMP-activated cation channel activity; • identical protein binding; • voltage-gated potassium channel activity; • voltage-gated sodium channel activity; • voltage-gated potassium channel activity involved in SA node cell action potential depolarization;
Cydrannau o'r gell	• integral component of membrane; • bilen; • intrinsic component of plasma membrane; • Cellbilen; • perinuclear region of cytoplasm; • HCN channel complex;
Prosesau biolegol	• cellular response to cGMP; • muscle contraction; • sodium ion transmembrane transport; • sodium ion transport; • SA node cell action potential; • regulation of membrane potential; • regulation of ion transmembrane transport; • cation transport; • cludo ïon; • blood circulation; • regulation of membrane depolarization; • regulation of heart rate; • potassium ion transport; • transmembrane transport; • potassium ion transmembrane transport; • regulation of cardiac muscle contraction; • regulation of heart rate by cardiac conduction; • cellular response to cAMP; • membrane depolarization during cardiac muscle cell action potential; • membrane depolarization during SA node cell action potential; • sodium ion import across plasma membrane; • regulation of cardiac muscle cell action potential involved in regulation of contraction; • potassium ion import across plasma membrane;
	Sources:Amigo / QuickGO
Orthologau
	10021
	n/a
	ENSG00000138622
	n/a
	Q9Y3Q4
	n/a
	NM_005477
	n/a
	NP_005468
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN4 yw HCN4 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium channel 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q24.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN4.

SSS2

Llyfryddiaeth

"Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels. ". J Biol Chem. 2015. PMID 25944904.
"The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. ". J Am Coll Cardiol. 2014. PMID 25145518.
"Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia. ". J Biol Chem. 2017. PMID 28174302.
"Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function. ". Pflugers Arch. 2016. PMID 27553229.
"HCN4 mutation as a molecular explanation on patients with bradycardia and non-compaction cardiomyopathy.". Eur J Med Genet. 2015. PMID 26206080.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] HCN4 - Cronfa NCBI

[1]

[2]