HCN4

HCN4
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2MNG, 3OTF, 3U11, 4HBN, 4KL1, 4NVP
Dynodwyr
Cyfenwau	HCN4, SSS2, hyperpolarization activated cyclic nucleotide gated potassium channel 4, BRGDA8, EIG18
Dynodwyr allanol	OMIM: 605206 HomoloGene: 3997 GeneCards: HCN4
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • potassium channel activity • cAMP binding • sodium channel activity • voltage-gated ion channel activity • ion channel activity • intracellular cAMP-activated cation channel activity • identical protein binding • voltage-gated potassium channel activity • voltage-gated sodium channel activity • voltage-gated potassium channel activity involved in SA node cell action potential depolarization Cydrannau o'r gell • integral component of membrane • bilen • intrinsic component of plasma membrane • Cellbilen • perinuclear region of cytoplasm • HCN channel complex Prosesau biolegol • cellular response to cGMP • muscle contraction • sodium ion transmembrane transport • sodium ion transport • SA node cell action potential • regulation of membrane potential • regulation of ion transmembrane transport • cation transport • cludo ïon • blood circulation • regulation of membrane depolarization • regulation of heart rate • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • regulation of cardiac muscle contraction • regulation of heart rate by cardiac conduction • cellular response to cAMP • membrane depolarization during cardiac muscle cell action potential • membrane depolarization during SA node cell action potential • sodium ion import across plasma membrane • regulation of cardiac muscle cell action potential involved in regulation of contraction • potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	10021	n/a
Ensembl	ENSG00000138622	n/a
UniProt	Q9Y3Q4	n/a
RefSeq (mRNA)	NM_005477	n/a
RefSeq (protein)	NP_005468	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN4 yw HCN4 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium channel 4 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 15, band 15q24.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN4.

• SSS2

Llyfryddiaeth

• "Role of Dynamics in the Autoinhibition and Activation of the Hyperpolarization-activated Cyclic Nucleotide-modulated (HCN) Ion Channels. ". J Biol Chem. 2015. PMID 25944904.
• "The symptom complex of familial sinus node dysfunction and myocardial noncompaction is associated with mutations in the HCN4 channel. ". J Am Coll Cardiol. 2014. PMID 25145518.
• "Free energy landscape remodeling of the cardiac pacemaker channel explains the molecular basis of familial sinus bradycardia. ". J Biol Chem. 2017. PMID 28174302.
• "Mutation in S6 domain of HCN4 channel in patient with suspected Brugada syndrome modifies channel function. ". Pflugers Arch. 2016. PMID 27553229.
• "HCN4 mutation as a molecular explanation on patients with bradycardia and non-compaction cardiomyopathy.". Eur J Med Genet. 2015. PMID 26206080.