HCN2

HCN2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2MPF, 3U10
Dynodwyr
Cyfenwau	HCN2, BCNG-2, BCNG2, HAC-1, hyperpolarization activated cyclic nucleotide gated potassium channel 2, hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2, EIG17, FEB2, GEFSP11
Dynodwyr allanol	OMIM: 602781 HomoloGene: 31022 GeneCards: HCN2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • potassium channel activity • cAMP binding • sodium channel activity • voltage-gated ion channel activity • ion channel activity • intracellular cAMP-activated cation channel activity • identical protein binding • voltage-gated potassium channel activity • voltage-gated sodium channel activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • integral component of membrane • bilen • voltage-gated potassium channel complex • Cellbilen • integral component of plasma membrane • HCN channel complex Prosesau biolegol • cellular response to cGMP • sodium ion transmembrane transport • sodium ion transport • cell-cell signaling • regulation of membrane potential • regulation of ion transmembrane transport • cludo ïon • potassium ion transport • transmembrane transport • potassium ion transmembrane transport • cellular response to cAMP • membrane depolarization during cardiac muscle cell action potential • sodium ion import across plasma membrane • potassium ion import across plasma membrane Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	610	n/a
Ensembl	ENSG00000099822	n/a
UniProt	Q9UL51	n/a
RefSeq (mRNA)	NM_001194	n/a
RefSeq (protein)	NP_001185	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN2 yw HCN2 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN2.

• BCNG2
• HAC-1
• BCNG-2

Llyfryddiaeth

• "Dual expression of constitutively active Gαs-protein-coupled receptors differentially establishes the resting activity of the cAMP-gated HCN2 channel in a single compartment. ". Biochem Biophys Res Commun. 2017. PMID 29054409.
• "Identification of methylated genes in salivary gland adenoid cystic carcinoma xenografts using global demethylation and methylation microarray screening. ". Int J Oncol. 2016. PMID 27212063.
• "Isoform dependent regulation of human HCN channels by cholesterol. ". Sci Rep. 2015. PMID 26404789.
• "Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart. ". Circ Arrhythm Electrophysiol. 2015. PMID 26304511.
• "HCN2 channels account for mechanical (but not heat) hyperalgesia during long-standing inflammation.". Pain. 2014. PMID 24525276.