HCN1

HCN1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3U0Z
Dynodwyr
Cyfenwau	HCN1, BCNG-1, BCNG1, EIEE24, HAC-2, hyperpolarization activated cyclic nucleotide gated potassium channel 1, GEFSP10, DEE24
Dynodwyr allanol	OMIM: 602780 HomoloGene: 32093 GeneCards: HCN1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • nucleotide binding • intracellular cAMP-activated cation channel activity • identical protein binding • voltage-gated sodium channel activity • ion channel activity • potassium channel activity • sodium channel activity • voltage-gated ion channel activity • voltage-gated potassium channel activity • voltage-gated cation channel activity • cAMP binding • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • axon • bilen • dendrite • Cellbilen • integral component of membrane • HCN channel complex • integral component of plasma membrane Prosesau biolegol • transmembrane transport • retinal cone cell development • regulation of ion transmembrane transport • apical protein localization • cludo ïon • sodium ion transport • regulation of membrane potential • sodium ion transmembrane transport • potassium ion transmembrane transport • potassium ion transport • protein homotetramerization • cellular response to cAMP Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	348980	n/a
Ensembl	ENSG00000164588	n/a
UniProt	O60741	n/a
RefSeq (mRNA)	NM_021072	n/a
RefSeq (protein)	NP_066550	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCN1 yw HCN1 a elwir hefyd yn Hyperpolarization activated cyclic nucleotide gated potassium channel 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCN1.

• BCNG1
• HAC-2
• BCNG-1
• EIEE24

Llyfryddiaeth

• "The magnitudes of hyperpolarization-activated and low-voltage-activated potassium currents co-vary in neurons of the ventral cochlear nucleus. ". J Neurophysiol. 2011. PMID 21562186.
• "Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain. ". J Neurosci. 2003. PMID 12598605.
• "A di-arginine ER retention signal regulates trafficking of HCN1 channels from the early secretory pathway to the plasma membrane. ". Cell Mol Life Sci. 2015. PMID 25142030.
• "De novo mutations in HCN1 cause early infantile epileptic encephalopathy. ". Nat Genet. 2014. PMID 24747641.
• "HCN1 channels: a new therapeutic target for depressive disorders?". Sci Signal. 2012. PMID 23033536.