HCK

HCK
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK
Dynodwyr
Cyfenwau	HCK, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
Dynodwyr allanol	OMIM: 142370 HomoloGene: 20489 GeneCards: HCK
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • non-membrane spanning protein tyrosine kinase activity • kinase activity • GO:0001948, GO:0016582 protein binding • signaling receptor binding • ATP binding • protein tyrosine kinase activity • phosphotyrosine residue binding Cydrannau o'r gell • cytoplasm • cytosol • Golgi apparatus • cell projection • bilen • focal adhesion • extrinsic component of cytoplasmic side of plasma membrane • transport vesicle • cell junction • Microffilament • caveola • lysosome • Cytosgerbwd • GO:0016023 cytoplasmic vesicle • cnewyllyn cell • nucleoplasm • Cellbilen Prosesau biolegol • cell differentiation • leukocyte migration involved in immune response • positive regulation of actin filament polymerization • Fc-gamma receptor signaling pathway involved in phagocytosis • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • cytokine-mediated signaling pathway • interferon-gamma-mediated signaling pathway • immune system process • leukocyte degranulation • negative regulation of apoptotic process • GO:0019049, GO:0030683 mitigation of host defenses by virus • protein phosphorylation • cell adhesion • respiratory burst after phagocytosis • regulation of DNA-binding transcription factor activity • positive regulation of cell population proliferation • regulation of inflammatory response • regulation of cell shape • regulation of podosome assembly • peptidyl-tyrosine autophosphorylation • ffagocytosis • integrin-mediated signaling pathway • protein autophosphorylation • peptidyl-tyrosine phosphorylation • regulation of phagocytosis • mesoderm development • inflammatory response • innate immune response-activating signal transduction • positive regulation of actin cytoskeleton reorganization • lipopolysaccharide-mediated signaling pathway • exocytosis • GO:0022415 viral process • innate immune response Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3055	n/a
Ensembl	ENSG00000101336	n/a
UniProt	P08631	n/a
RefSeq (mRNA)	NM_002110 NM_001172129 NM_001172130 NM_001172131 NM_001172132 NM_001172133	n/a
RefSeq (protein)	NP_001165600 NP_001165601 NP_001165602 NP_001165603 NP_001165604 NP_002101	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HCK yw HCK a elwir hefyd yn HCK proto-oncogene, Src family tyrosine kinase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 20, band 20q11.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HCK.

• JTK9
• p59Hck
• p61Hck

Llyfryddiaeth

• "Novel virtual lead identification in the discovery of hematopoietic cell kinase (HCK) inhibitors: application of 3D QSAR and molecular dynamics simulation. ". J Recept Signal Transduct Res. 2017. PMID 27485399.
• "Hematopoietic cell kinase gene polymorphisms and the risk of chronic obstructive pulmonary disease in a Chinese population. ". Exp Lung Res. 2012. PMID 22185326.
• "Regulation of the hematopoietic cell kinase (HCK) by PML/RARα and PU.1 in acute promyelocytic leukemia. ". Leuk Res. 2012. PMID 21993313.
• "Hck is a key regulator of gene expression in alternatively activated human monocytes. ". J Biol Chem. 2011. PMID 21878628.
• "Multidomain assembled states of Hck tyrosine kinase in solution.". Proc Natl Acad Sci U S A. 2010. PMID 20798061.