HBEGF

HBEGF
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1XDT, 2M8S
Dynodwyr
Cyfenwau	HBEGF, DTR, DTS, DTSF, HEGFL, heparin binding EGF like growth factor
Dynodwyr allanol	OMIM: 126150 HomoloGene: 1466 GeneCards: HBEGF
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • growth factor activity • heparin binding • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • epidermal growth factor receptor binding Cydrannau o'r gell • extracellular region • endocytic vesicle membrane • integral component of membrane • bilen • cell surface • Cellbilen • clathrin-coated endocytic vesicle membrane • integral component of plasma membrane • extracellular space • clathrin-coated vesicle membrane Prosesau biolegol • positive regulation of keratinocyte migration • cell chemotaxis • MAPK cascade • GO:0072468 signal transduction • wound healing, spreading of epidermal cells • positive regulation of cell migration • positive regulation of cell growth • muscle organ development • positive regulation of smooth muscle cell proliferation • regulation of heart contraction • negative regulation of elastin biosynthetic process • cell migration • positive regulation of wound healing • epidermal growth factor receptor signaling pathway • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • peptidyl-tyrosine phosphorylation • regulation of cell motility • positive regulation of cell population proliferation • positive regulation of peptidyl-tyrosine phosphorylation • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • negative regulation of epidermal growth factor receptor signaling pathway • membrane organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	1839	n/a
Ensembl	ENSG00000113070	n/a
UniProt	Q99075	n/a
RefSeq (mRNA)	NM_001945	n/a
RefSeq (protein)	NP_001936	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HBEGF yw HBEGF a elwir hefyd yn Heparin binding EGF like growth factor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 5, band 5q31.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HBEGF.

• DTR
• DTS
• DTSF
• HEGFL

Llyfryddiaeth

• "Serum Heparin-binding Epidermal Growth Factor-like Growth Factor (HB-EGF) as a Biomarker for Primary Ovarian Cancer. ". Anticancer Res. 2017. PMID 28668900.
• "HBEGF promotes gliomagenesis in the context of Ink4a/Arf and Pten loss. ". Oncogene. 2017. PMID 28368403.
• "Heparin-binding epidermal growth factor-like growth factor promotes neuroblastoma differentiation. ". FASEB J. 2017. PMID 28174207.
• "Regulation of HBEGF by Micro-RNA for Survival of Developing Human Trophoblast Cells. ". PLoS One. 2016. PMID 27701455.
• "Anti-Human HB-EGF Monoclonal Antibody.". Monoclon Antib Immunodiagn Immunother. 2016. PMID 27097072.