HAMP

HAMP
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1M4E, 1M4F, 2KEF, 3H0T, 4QAE
Dynodwyr
Cyfenwau	HAMP, HEPC, HFE2B, LEAP1, PLTR, hepcidin antimicrobial peptide
Dynodwyr allanol	OMIM: 606464 HomoloGene: 81623 GeneCards: HAMP
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • hormone activity • iron ion transmembrane transporter inhibitor activity • signaling receptor binding Cydrannau o'r gell • cytoplasm • extracellular region • apical cortex • intercalated disc • extracellular space Prosesau biolegol • negative regulation of iron export across plasma membrane • negative regulation of intestinal absorption • positive regulation of receptor internalization • GO:1901227 negative regulation of transcription by RNA polymerase II • negative regulation of iron ion transmembrane transporter activity • response to iron ion • multicellular organismal iron ion homeostasis • defense response to bacterium • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of receptor catabolic process • positive regulation of protein polyubiquitination • negative regulation of ion transmembrane transporter activity • cellular iron ion homeostasis • cellular response to lipopolysaccharide • GO:0010260 heneiddio • cellular response to tumor necrosis factor • liver regeneration • cellular response to bile acid • cellular response to interleukin-6 • response to iron ion starvation • response to vitamin A • response to erythropoietin • positive regulation of cell growth involved in cardiac muscle cell development • response to ethanol • acute-phase response • cellular response to X-ray • response to zinc ion • negative regulation of iron ion transmembrane transport • antimicrobial humoral immune response mediated by antimicrobial peptide • killing of cells of other organism • defense response to fungus • regulation of signaling receptor activity • GO:0072468 signal transduction Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	57817	n/a
Ensembl	ENSG00000105697	n/a
UniProt	P81172	n/a
RefSeq (mRNA)	NM_021175	n/a
RefSeq (protein)	NP_066998	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn HAMP yw HAMP a elwir hefyd yn Hepcidin antimicrobial peptide (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn HAMP.

• HEPC
• PLTR
• HFE2B
• LEAP1

Llyfryddiaeth

• "Identification of novel bone morphogenetic protein- responsive elements in a hepcidin promoter. ". FEBS Lett. 2017. PMID 29105755.
• "Association of Single-Nucleotide Polymorphism in the Hepcidin Promoter Gene with Susceptibility to Extrapulmonary Tuberculosis. ". Genet Test Mol Biomarkers. 2017. PMID 28530443.
• "Hepcidin: Homeostasis and Diseases Related to Iron Metabolism. ". Acta Haematol. 2017. PMID 28514781.
• "Reciprocal regulation between hepcidin and erythropoiesis and its therapeutic application in erythroid disorders. ". Exp Hematol. 2017. PMID 28501597.
• "Hepcidin plasma levels are not associated with changes in haemoglobin in early rheumatoid arthritis patients.". Scand J Rheumatol. 2017. PMID 28482738.