H2AFX

H2AX
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2D31, 2DYP, 3SHV, 3SQD, 3SZM, 1YDP, 2AZM, 3U3Z
Dynodwyr
Cyfenwau	H2AX, H2A.X, H2A/X, H2A histone family member X, H2A.X variant histone, H2AFX
Dynodwyr allanol	OMIM: 601772 HomoloGene: 134201 GeneCards: H2AX
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • GO:0031493 histone binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • enzyme binding • damaged DNA binding Cydrannau o'r gell • nucleoplasm • Cromosom • telomere • nucleosome • extracellular exosome • nuclear speck • centrosome • cnewyllyn cell • site of double-strand break • chromatin • condensed nuclear chromosome • male germ cell nucleus • XY body • replication fork • site of DNA damage Prosesau biolegol • response to ionizing radiation • nucleosome assembly • DNA recombination • DNA damage checkpoint signaling • GO:1900404 positive regulation of DNA repair • cellular response to DNA damage stimulus • cellular senescence • GO:0007126 Meiosis • cellular response to gamma radiation • spermatogenesis • cerebral cortex development • cell cycle • GO:0022415 viral process • double-strand break repair via nonhomologous end joining • double-strand break repair • GO:0100026 DNA repair • double-strand break repair via homologous recombination • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3014	n/a
Ensembl	ENSG00000188486	n/a
UniProt	P16104	n/a
RefSeq (mRNA)	NM_002105	n/a
RefSeq (protein)	NP_002096	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn H2AFX yw H2AFX a elwir hefyd yn H2A histone family member X (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 11, band 11q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn H2AFX.

• H2AX
• H2A.X
• H2A/X

Llyfryddiaeth

• "gamma-H2AX: Can it be established as a classical cancer prognostic factor?". Tumour Biol. 2017. PMID 28351323.
• "Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. ". PLoS One. 2016. PMID 27907109.
• "Phosphorylation of H2A.XTyr39 positively regulates DNA damage response and is linked to cancer progression. ". FEBS J. 2016. PMID 27813335.
• "Effect of mild temperature shift on poly(ADP-ribose) and γH2AX levels in cultured cells. ". Biochem Biophys Res Commun. 2016. PMID 27262441.
• "Phosphorylation of gH2AX as a novel prognostic biomarker for laryngoesophageal dysfunction-free survival.". Oncotarget. 2016. PMID 27166270.