GZMM

GZMM
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ZGC, 2ZGH, 2ZGJ, 2ZKS
Dynodwyr
Cyfenwau	GZMM, LMET1, MET1, granzyme M
Dynodwyr allanol	OMIM: 600311 HomoloGene: 21099 GeneCards: GZMM
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • serine-type peptidase activity • endopeptidase activity • serine-type endopeptidase activity • hydrolase activity • GO:0001948, GO:0016582 protein binding Cydrannau o'r gell • extracellular region • bilen Prosesau biolegol • innate immune response • marwolaeth celloedd • cytolysis • proteolysis • immune system process • GO:0097285 apoptotic process • T cell mediated cytotoxicity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3004	n/a
Ensembl	ENSG00000197540	n/a
UniProt	P51124	n/a
RefSeq (mRNA)	NM_005317 NM_001258351	n/a
RefSeq (protein)	NP_001245280 NP_005308	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GZMM yw GZMM a elwir hefyd yn Granzyme M (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GZMM.

• MET1
• LMET1

Llyfryddiaeth

• "Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. ". Biochem Biophys Res Commun. 2016. PMID 27133719.
• "Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation. ". Clin Immunol. 2014. PMID 24316590.
• "Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71. ". J Immunol. 2010. PMID 21059895.
• "Granzyme M: characterization with sites of post-translational modification and specific sites of interaction with substrates and inhibitors. ". Mol Biol Rep. 2011. PMID 20107908.
• "The cytotoxic protease granzyme M is expressed by lymphocytes of both the innate and adaptive immune system.". Mol Immunol. 2010. PMID 19896187.