GZMB

GZMB
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1FQ3, 1IAU
Dynodwyr
Cyfenwau	GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, granzyme B, C11
Dynodwyr allanol	OMIM: 123910 HomoloGene: 108184 GeneCards: GZMB
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity Cydrannau o'r gell • cytosol • bilen • immunological synapse • cnewyllyn cell • mitocondria • secretory granule • cytoplasm Prosesau biolegol • cytolysis • proteolysis • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway • natural killer cell mediated cytotoxicity • GO:0097285 apoptotic process • granzyme-mediated apoptotic signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3002	n/a
Ensembl	ENSG00000100453	n/a
UniProt	P10144	n/a
RefSeq (mRNA)	NM_004131 NM_001346011	n/a
RefSeq (protein)	NP_001332940 NP_004122	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GZMB yw GZMB a elwir hefyd yn Granzyme B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GZMB.

• C11
• HLP
• CCPI
• CGL1
• CSPB
• SECT
• CGL-1
• CSP-B
• CTLA1
• CTSGL1

Llyfryddiaeth

• "Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. ". Cancer Res. 2017. PMID 28461564.
• "Relationships among plasma granzyme B level, pruritus and dermatitis in patients with atopic dermatitis. ". J Dermatol Sci. 2016. PMID 27686401.
• "Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. ". PLoS One. 2016. PMID 27310868.
• "[Rapid biosynthesis and release of 35 kD granzyme B by NK92 cells bypassing secretory lysosomes]. ". Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2016. PMID 26927382.
• "Increased IL-21 Expression Induces Granzyme B in Peripheral CD5(+) B Cells as a Potential Counter-Regulatory Effect in Primary Sjögren's Syndrome.". Mediators Inflamm. 2016. PMID 26884645.