GZMA

GZMA
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1OP8, 1ORF
Dynodwyr
Cyfenwau	GZMA, CTLA3, HFSP, granzyme A
Dynodwyr allanol	OMIM: 140050 HomoloGene: 21237 GeneCards: GZMA
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0070122 peptidase activity • serine-type peptidase activity • serine-type endopeptidase activity • hydrolase activity • GO:0001948, GO:0016582 protein binding • protein homodimerization activity Cydrannau o'r gell • immunological synapse • extracellular region • cnewyllyn cell Prosesau biolegol • positive regulation of apoptotic process • negative regulation of DNA binding • proteolysis involved in cellular protein catabolic process • negative regulation of endodeoxyribonuclease activity • cytolysis • GO:2001216 negative regulation of oxidoreductase activity • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • proteolysis • GO:0097285 apoptotic process • response to bacterium Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3001	n/a
Ensembl	ENSG00000145649	n/a
UniProt	P12544	n/a
RefSeq (mRNA)	NM_006144	n/a
RefSeq (protein)	NP_006135	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GZMA yw GZMA a elwir hefyd yn Granzyme A (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q11.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GZMA.

• HFSP
• CTLA3

Llyfryddiaeth

• "Granzyme A as a potential biomarker of Mycobacterium tuberculosis infection and disease. ". Immunol Lett. 2015. PMID 26051682.
• "The substrate specificity profile of human granzyme A. ". Biol Chem. 2010. PMID 20536382.
• "Granzyme A is a proinflammatory protease. ". Blood. 2009. PMID 19875524.
• "Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release. ". Biosci Biotechnol Biochem. 2008. PMID 18776661.
• "Glucocorticoid-induced alternative promoter usage for a novel 5' variant of granzyme A.". J Hum Genet. 2007. PMID 17180578.