GTF2A1

GTF2A1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1NVP, 5IYB, 5IYC, 5IY9, 5IY8, 5IY7, 5IYD, 5IY6, 5FUR, 5IYA
Dynodwyr
Cyfenwau	GTF2A1, TF2A1, TFIIA, TFIIA-42, TFIIAL, general transcription factor IIA subunit 1
Dynodwyr allanol	OMIM: 600520 HomoloGene: 56331 GeneCards: GTF2A1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • TBP-class protein binding • DNA binding • GO:0001105 transcription coactivator activity • transcription factor binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • GO:0000983 RNA polymerase II general transcription initiation factor activity Cydrannau o'r gell • transcription factor TFIIA complex • cnewyllyn cell • nucleoplasm • transcription factor TFIID complex • cytosol • cytoplasm Prosesau biolegol • transcription initiation from RNA polymerase II promoter • GO:0009373 regulation of transcription, DNA-templated • transcription by RNA polymerase II • transcription, DNA-templated • snRNA transcription by RNA polymerase II • positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2957	n/a
Ensembl	ENSG00000165417	n/a
UniProt	P52655	n/a
RefSeq (mRNA)	NM_201595 NM_001278940 NM_015859	n/a
RefSeq (protein)	NP_001265869 NP_056943 NP_963889	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GTF2A1 yw GTF2A1 a elwir hefyd yn General transcription factor IIA subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 14, band 14q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GTF2A1.

• TF2A1
• TFIIA
• TFIIAL
• TFIIA-42

Llyfryddiaeth

• "Cleavage and proteasome-mediated degradation of the basal transcription factor TFIIA. ". EMBO J. 2004. PMID 15257296.
• "Human genome search in celiac disease: mutated gliadin T-cell-like epitope in two human proteins promotes T-cell activation. ". J Mol Biol. 2002. PMID 12054857.
• "Ubiquitin-proteasome-dependent degradation of TBP-like protein is prevented by direct binding of TFIIA. ". Genes Cells. 2016. PMID 27696626.
• "Activity of the upstream TATA-less promoter of the p21(Waf1/Cip1) gene depends on transcription factor IIA (TFIIA) in addition to TFIIA-reactive TBP-like protein. ". FEBS J. 2014. PMID 24835508.
• "Identification of candidate epigenetic biomarkers for ovarian cancer detection.". Oncol Rep. 2009. PMID 19724865.