GSTP1

GSTP1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	10GS, 11GS, 12GS, 13GS, 14GS, 16GS, 17GS, 18GS, 19GS, 1AQV, 1AQW, 1AQX, 1EOG, 1EOH, 1GSS, 1KBN, 1LBK, 1MD3, 1MD4, 1PGT, 1PX6, 1PX7, 1ZGN, 20GS, 22GS, 2A2R, 2A2S, 2GSS, 2J9H, 2PGT, 3CSH, 3CSI, 3CSJ, 3DD3, 3DGQ, 3GSS, 3GUS, 3HJM, 3HJO, 3HKR, 3IE3, 3KM6, 3KMN, 3KMO, 3N9J, 3PGT, 4GSS, 4PGT, 5GSS, 6GSS, 7GSS, 8GSS, 9GSS
Dynodwyr
Cyfenwau	GSTP1, DFN7, FAEES3, GST3, GSTP, HEL-S-22, PI, glutathione S-transferase pi 1
Dynodwyr allanol	OMIM: 134660 HomoloGene: 660 GeneCards: GSTP1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • JUN kinase binding; • kinase regulator activity; • glutathione binding; • nitric oxide binding; • GO:0001948, GO:0016582 protein binding; • S-nitrosoglutathione binding; • dinitrosyl-iron complex binding; • glutathione transferase activity; • protein kinase binding; • glutathione peroxidase activity;
Cydrannau o'r gell	• fesigl; • TRAF2-GSTP1 complex; • Cellbilen; • intracellular anatomical structure; • mitocondria; • extracellular exosome; • cnewyllyn cell; • extracellular region; • extracellular space; • cytoplasm; • cytosol; • secretory granule lumen; • ficolin-1-rich granule lumen;
Prosesau biolegol	• negative regulation of monocyte chemotactic protein-1 production; • cellular response to cell-matrix adhesion; • response to amino acid; • response to estradiol; • negative regulation of interleukin-1 beta production; • negative regulation of acute inflammatory response; • glutathione metabolic process; • negative regulation of tumor necrosis factor-mediated signaling pathway; • negative regulation of leukocyte proliferation; • common myeloid progenitor cell proliferation; • nitric oxide storage; • negative regulation of extrinsic apoptotic signaling pathway; • negative regulation of apoptotic process; • response to L-ascorbic acid; • negative regulation of I-kappaB kinase/NF-kappaB signaling; • cellular response to epidermal growth factor stimulus; • central nervous system development; • cellular response to glucocorticoid stimulus; • response to nutrient levels; • negative regulation of MAP kinase activity; • animal organ regeneration; • regulation of ERK1 and ERK2 cascade; • cellular response to insulin stimulus; • negative regulation of MAPK cascade; • negative regulation of ERK1 and ERK2 cascade; • negative regulation of stress-activated MAPK cascade; • oligodendrocyte development; • positive regulation of superoxide anion generation; • negative regulation of tumor necrosis factor production; • metabolaeth; • response to ethanol; • cellular response to lipopolysaccharide; • negative regulation of JUN kinase activity; • negative regulation of fibroblast proliferation; • negative regulation of nitric-oxide synthase biosynthetic process; • glutathione derivative biosynthetic process; • response to toxic substance; • regulation of stress-activated MAPK cascade; • negative regulation of biosynthetic process; • cellular oxidant detoxification; • negative regulation of protein kinase activity; • xenobiotic metabolic process; • negative regulation of smooth muscle cell chemotaxis; • linoleic acid metabolic process; • negative regulation of vascular associated smooth muscle cell proliferation; • neutrophil degranulation; • GO:0001315 response to reactive oxygen species; • cellular response to oxidative stress; • xenobiotic catabolic process;
	Sources:Amigo / QuickGO
Orthologau
	2950
	n/a
	ENSG00000084207
	n/a
	P09211
	n/a
	NM_000852
	n/a
	NP_000843
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSTP1 yw GSTP1 a elwir hefyd yn Glutathione S-transferase pi 1 a Glutathione S-transferase P (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GSTP1.

PI
DFN7
GST3
GSTP
FAEES3
HEL-S-22

Llyfryddiaeth[golygu | golygu cod]

"Synergic effect of oral contraceptives, GSTP1 polymorphisms, and high-risk HPV infection in development of cervical lesions. ". Genet Mol Res. 2017. PMID 28829907.
"GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck. ". PLoS One. 2017. PMID 28817620.
"Promoter methylation and gene polymorphism are two independent events in regulation of GSTP1 gene expression. ". Tumour Biol. 2017. PMID 28443466.
"Glutathione S-transferase P1 Ile105Val Polymorphism and Male Infertility Risk: An Updated Meta-analysis. ". Chin Med J (Engl). 2017. PMID 28397729.
"Energy landscape of a GSTP1 polymorph linked with cytological function decay in response to chemical stressors.". Gene. 2017. PMID 28153749.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] GSTP1 - Cronfa NCBI

[1]

[2]