GSTO1

GSTO1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1EEM, 3LFL, 3VLN, 4IS0
Dynodwyr
Cyfenwau	GSTO1, GSTO 1-1, GSTTLp28, HEL-S-21, P28, SPG-R, glutathione S-transferase omega 1
Dynodwyr allanol	OMIM: 605482 HomoloGene: 37971 GeneCards: GSTO1
EC number	1.20.4.2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • glutathione dehydrogenase (ascorbate) activity • GO:0001948, GO:0016582 protein binding • methylarsonate reductase activity • oxidoreductase activity • glutathione transferase activity Cydrannau o'r gell • cytoplasm • cytosol • extracellular exosome Prosesau biolegol • xenobiotic catabolic process • regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion • negative regulation of ryanodine-sensitive calcium-release channel activity • positive regulation of ryanodine-sensitive calcium-release channel activity • methylation • cellular response to arsenic-containing substance • positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion • metabolaeth • regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum • glutathione derivative biosynthetic process • L-ascorbic acid metabolic process • cellular oxidant detoxification • glutathione metabolic process • toxin catabolic process • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9446	n/a
Ensembl	ENSG00000148834	n/a
UniProt	P78417 Q5TA02	n/a
RefSeq (mRNA)	NM_004832 NM_001191002 NM_001191003	n/a
RefSeq (protein)	NP_001177931 NP_001177932 NP_004823	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSTO1 yw GSTO1 a elwir hefyd yn Glutathione S-transferase omega-1 a Glutathione S-transferase omega 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 10, band 10q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GSTO1.

• P28
• SPG-R
• GSTO*1-1
• GSTTLp28
• HEL-S-21

Llyfryddiaeth

• "A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle. ". J Biol Chem. 2013. PMID 23888047.
• "Association between glutathione S-transferase omega 1 A140D polymorphism in the Turkish population and susceptibility to non-small cell lung cancer. ". Arh Hig Rada Toksikol. 2013. PMID 23819933.
• "Genetic polymorphisms in Glutathione S-transferase Omega (GSTO) and cancer risk: a meta-analysis of 20 studies. ". Sci Rep. 2014. PMID 25300926.
• "Identification of glutathione S-transferase omega 1 (GSTO1) protein as a novel tumor-associated antigen and its autoantibody in human esophageal squamous cell carcinoma. ". Tumour Biol. 2014. PMID 25085586.
• "GSTO1 uncommon genetic variants are associated with recurrent miscarriage risk.". Fertil Steril. 2014. PMID 24417908.