GSR

GSR
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1BWC, 1DNC, 1GRA, 1GRB, 1GRE, 1GRF, 1GRG, 1GRH, 1GRT, 1GSN, 1K4Q, 1XAN, 2AAQ, 2GH5, 2GRT, 3DJG, 3DJJ, 3DK4, 3DK8, 3DK9, 3GRS, 3GRT, 4GR1, 4GRT, 5GRT, 1ALG, 3SQP
Dynodwyr
Cyfenwau	GSR, HEL-75, HEL-S-122m, glutathione reductase, glutathione-disulfide reductase, GR, GSRD
Dynodwyr allanol	OMIM: 138300 HomoloGene: 531 GeneCards: GSR
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • flavin adenine dinucleotide binding • glutathione-disulfide reductase (NADPH) activity • NADP binding • oxidoreductase activity • oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor • electron transfer activity Cydrannau o'r gell • cytoplasm • cytosol • mitochondrial matrix • mitocondria • extracellular exosome • external side of plasma membrane Prosesau biolegol • nucleobase-containing small molecule interconversion • glutathione metabolic process • cell redox homeostasis • cellular oxidant detoxification • cellular response to oxidative stress • electron transport chain Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2936	n/a
Ensembl	ENSG00000104687	n/a
UniProt	P00390	n/a
RefSeq (mRNA)	NM_001195104 NM_000637 NM_001195102 NM_001195103	n/a
RefSeq (protein)	NP_000628 NP_001182031 NP_001182032 NP_001182033	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSR yw GSR a elwir hefyd yn Glutathione-disulfide reductase (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8p12.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GSR.

• HEL-75
• HEL-S-122m

Llyfryddiaeth

• "Glutathione reductase mediates drug resistance in glioblastoma cells by regulating redox homeostasis. ". J Neurochem. 2018. PMID 29105080.
• "Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry. ". J Rheumatol. 2013. PMID 23637325.
• "Expression of glutathione reductase splice variants in human tissues. ". Biochem Genet. 2010. PMID 20628807.
• "Age-dependent denaturation of enzymes in the human lens: a paradigm for organismic aging?". Rejuvenation Res. 2010. PMID 20586645.
• "Inherited glutathione reductase deficiency and Plasmodium falciparum malaria--a case study.". PLoS One. 2009. PMID 19806191.