GSK3B

GSK3B
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1GNG, 1H8F, 1I09, 1J1B, 1J1C, 1O6K, 1O6L, 1O9U, 1PYX, 1Q3D, 1Q3W, 1Q41, 1Q4L, 1Q5K, 1R0E, 1UV5, 2JDO, 2JDR, 2JLD, 2O5K, 2OW3, 2UW9, 2X39, 2XH5, 3CQU, 3CQW, 3DU8, 3E87, 3E88, 3E8D, 3F7Z, 3F88, 3GB2, 3I4B, 3L1S, 3M1S, 3MV5, 3OW4, 3PUP, 3Q3B, 3QKK, 3SAY, 3SD0, 3ZDI, 3ZRK, 3ZRL, 3ZRM, 4ACC, 4ACD, 4ACG, 4ACH, 4AFJ, 4B7T, 4DIT, 4EKK, 4IQ6, 4J1R, 4J71, 4NM0, 4NM3, 4NM5, 4NM7, 4PTC, 4PTE, 4PTG, 5F94, 5F95, 5HLP, 5HLN
Dynodwyr
Cyfenwau	GSK3B, Gsk3b, 7330414F15Rik, 8430431H08Rik, C86142, GSK-3, GSK-3beta, GSK3, glycogen synthase kinase 3 beta
Dynodwyr allanol	OMIM: 605004 HomoloGene: 55629 GeneCards: GSK3B
EC number	2.7.11.1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • kinase activity • ATP binding • protein kinase activity • protein kinase A catalytic subunit binding • protein serine/threonine kinase activity • transferase activity • NF-kappaB binding • tau-protein kinase activity • GO:0001948, GO:0016582 protein binding • nucleotide binding • p53 binding • ubiquitin protein ligase binding • protease binding • beta-catenin binding • protein kinase binding • dynactin binding • tau protein binding Cydrannau o'r gell • cytoplasm • bilen • mitocondria • cnewyllyn cell • centrosome • Cellbilen • cytosol • beta-catenin destruction complex • postsynapse • Wnt signalosome • nucleoplasm • axon • dendrite • glutamatergic synapse Prosesau biolegol • proses rythmig • negative regulation of type B pancreatic cell development • negative regulation of protein binding • negative regulation of glycogen (starch) synthase activity • glycogen metabolic process • superior temporal gyrus development • negative regulation of canonical Wnt signaling pathway • chemical synaptic transmission, postsynaptic • GO:0106160 negative regulation of protein-containing complex assembly • positive regulation of protein export from nucleus • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • protein autophosphorylation • cell differentiation • negative regulation of protein localization to nucleus • phosphorylation • positive regulation of cell-matrix adhesion • nervous system development • dopamine receptor signaling pathway • epithelial to mesenchymal transition • peptidyl-threonine phosphorylation • positive regulation of protein-containing complex assembly • positive regulation of neuron death • negative regulation of glycogen biosynthetic process • multicellular organism development • regulation of cellular response to heat • negative regulation of signal transduction • hippocampus development • beta-catenin destruction complex disassembly • proteasome-mediated ubiquitin-dependent protein catabolic process • Wnt signaling pathway • beta-catenin destruction complex assembly • protein phosphorylation • positive regulation of mitochondrion organization • GO:0007243 intracellular signal transduction • GO:1903364 positive regulation of protein catabolic process • negative regulation of dopaminergic neuron differentiation • ER overload response • Rhythm circadaidd • GO:0035404 peptidyl-serine phosphorylation • positive regulation of protein binding • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • regulation of microtubule-based process • cellular response to interleukin-3 • negative regulation of apoptotic process • canonical Wnt signaling pathway • extrinsic apoptotic signaling pathway in absence of ligand • positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway • carbohydrate metabolic process • neuron projection development • negative regulation of neuron death • GO:1901313 positive regulation of gene expression • establishment of cell polarity • maintenance of cell polarity • regulation of axon extension • negative regulation of phosphoprotein phosphatase activity • regulation of dendrite morphogenesis • regulation of axonogenesis • excitatory postsynaptic potential • regulation of microtubule cytoskeleton organization • negative regulation of calcineurin-NFAT signaling cascade • extrinsic apoptotic signaling pathway • neuron projection retraction • negative regulation of protein acetylation • cellular response to amyloid-beta • positive regulation of protein localization to centrosome • regulation of synaptic vesicle exocytosis • neuron projection organization • positive regulation of autophagy • regulation of circadian rhythm • regulation of long-term synaptic potentiation • regulation of microtubule anchoring at centrosome Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2932	n/a
Ensembl	ENSG00000082701	n/a
UniProt	P49841	n/a
RefSeq (mRNA)	NM_001146156 NM_002093 NM_001354596	n/a
RefSeq (protein)	NP_001139628 NP_002084 NP_001341525	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GSK3B yw GSK3B a elwir hefyd yn Glycogen synthase kinase 3 beta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 3, band 3q13.33.

Llyfryddiaeth

• "Role of GSK3β in breast cancer susceptibility. ". Cancer Biomark. 2017. PMID 27983530.
• "Anti-inflammatory and anticancer effects of flavonol glycosides from Diplotaxis harra through GSK3β regulation in intestinal cells. ". Pharm Biol. 2017. PMID 27925497.
• "Biological basis and clinical study of glycogen synthase kinase- 3β-targeted therapy by drug repositioning for glioblastoma. ". Oncotarget. 2017. PMID 28423558.
• "The gender-specific association of rs334558 in GSK3β with major depressive disorder. ". Medicine (Baltimore). 2017. PMID 28099358.
• "GSK-3β Interacts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia.". CNS Neurosci Ther. 2017. PMID 27996211.