GRM1

GRM1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 3KS9, 4OR2
Dynodwyr
Cyfenwau	GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1, SCA44
Dynodwyr allanol	OMIM: 604473 HomoloGene: 649 GeneCards: GRM1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • glutamate receptor activity • G protein-coupled receptor activity • signal transducer activity • GO:0001948, GO:0016582 protein binding • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration • identical protein binding • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential Cydrannau o'r gell • integral component of membrane • G protein-coupled receptor dimeric complex • GO:0097483, GO:0097481 postsynaptic density • bilen • G protein-coupled receptor homodimeric complex • Cellbilen • integral component of plasma membrane • dendrite • neuron projection • cnewyllyn cell • presynaptic membrane • Schaffer collateral - CA1 synapse • glutamatergic synapse • postsynaptic density membrane Prosesau biolegol • cellular response to electrical stimulus • G protein-coupled glutamate receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway • regulation of MAPK cascade • regulation of sensory perception of pain • locomotory behavior • sensory perception of pain • GO:0072468 signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway • regulation of postsynaptic cytosolic calcium ion concentration • G protein-coupled receptor signaling pathway • regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2911	n/a
Ensembl	ENSG00000152822	n/a
UniProt	Q13255	n/a
RefSeq (mRNA)	NM_000838 NM_001114329 NM_001278064 NM_001278065 NM_001278066 NM_001278067	n/a
RefSeq (protein)	NP_001264993 NP_001264994 NP_001264995 NP_001264996	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRM1 yw GRM1 a elwir hefyd yn Glutamate metabotropic receptor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q24.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRM1.

• MGLU1
• SCA44
• GPRC1A
• MGLUR1
• SCAR13
• PPP1R85

Llyfryddiaeth

• "Dominant Mutations in GRM1 Cause Spinocerebellar Ataxia Type 44. ". Am J Hum Genet. 2017. PMID 28886343.
• "Age and gender effects of 11C-ITMM binding to metabotropic glutamate receptor type 1 in healthy human participants. ". Neurobiol Aging. 2017. PMID 28431287.
• "Are Type 1 metabotropic glutamate receptors a viable therapeutic target for the treatment of cerebellar ataxia?". J Physiol. 2016. PMID 26748626.
• "Atypical signaling of metabotropic glutamate receptor 1 in human melanoma cells. ". Biochem Pharmacol. 2015. PMID 26291396.
• "Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells.". Breast Cancer Res Treat. 2015. PMID 25859923.