GRK2

GRK2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4PNK, 1BAK, 3CIK, 3KRW, 3KRX, 3V5W, 4MK0, 5HE1
Dynodwyr
Cyfenwau	GRK2, BARK1, BETA-ARK1, ADRBK1, G protein-coupled receptor kinase 2
Dynodwyr allanol	OMIM: 109635 HomoloGene: 1223 GeneCards: GRK2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • Edg-2 lysophosphatidic acid receptor binding • protein kinase activity • nucleotide binding • G protein-coupled receptor kinase activity • kinase activity • protein serine/threonine kinase activity • GO:0001948, GO:0016582 protein binding • alpha-2A adrenergic receptor binding • ATP binding • beta-adrenergic receptor kinase activity Cydrannau o'r gell • cytoplasm • cytosol • bilen • Cellbilen • cilium Prosesau biolegol • G protein-coupled acetylcholine receptor signaling pathway • cardiac muscle contraction • phosphorylation • regulation of the force of heart contraction • viral genome replication • negative regulation of striated muscle contraction • positive regulation of catecholamine secretion • receptor internalization • tachykinin receptor signaling pathway • protein phosphorylation • heart development • GO:0035404 peptidyl-serine phosphorylation • viral entry into host cell • desensitization of G protein-coupled receptor signaling pathway • peptidyl-threonine phosphorylation • negative regulation of the force of heart contraction by chemical signal • GO:0072468 signal transduction • G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	156	n/a
Ensembl	ENSG00000173020	n/a
UniProt	P25098	n/a
RefSeq (mRNA)	NM_001619	n/a
RefSeq (protein)	NP_001610	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRK2 yw GRK2 a elwir hefyd yn G protein-coupled receptor kinase 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRK2.

• BARK1
• ADRBK1
• BETA-ARK1

Llyfryddiaeth

• "G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis. ". EBioMedicine. 2016. PMID 27720394.
• "Role of amino acid residues surrounding the phosphorylation site in peptide substrates of G protein-coupled receptor kinase 2 (GRK2). ". Amino Acids. 2016. PMID 27714516.
• "G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. ". J Med Chem. 2016. PMID 27362616.
• "G-protein-coupled receptor kinase 2 in pancreatic cancer: clinicopathologic and prognostic significance. ". Hum Pathol. 2016. PMID 27346572.
• "G protein-coupled receptor kinase-2 in peripheral blood mononuclear cells following acute mental stress.". Life Sci. 2016. PMID 26706289.