GRIK2

GRIK2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3QXM, 5CMM
Dynodwyr
Cyfenwau	GRIK2, EAA4, GLR6, GLUK6, GLUR6, GluK2, MRT6, glutamate ionotropic receptor kainate type subunit 2, NEDLAS
Dynodwyr allanol	OMIM: 138244 HomoloGene: 40717 GeneCards: GRIK2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• glutamate receptor activity; • PDZ domain binding; • kainate selective glutamate receptor activity; • protein homodimerization activity; • ion channel activity; • ionotropic glutamate receptor activity; • identical protein binding; • ligand-gated ion channel activity; • extracellularly glutamate-gated ion channel activity; • signaling receptor activity; • ubiquitin conjugating enzyme binding; • ubiquitin protein ligase binding; • ligand-gated ion channel activity involved in regulation of presynaptic membrane potential; • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cydrannau o'r gell	• integral component of membrane; • perikaryon; • postsynaptic membrane; • bilen; • Cellbilen; • synapse; • integral component of plasma membrane; • cell junction; • terminal bouton; • axon; • dendrite; • dendrite cytoplasm; • ionotropic glutamate receptor complex; • GO:0097483, GO:0097481 postsynaptic density; • kainate selective glutamate receptor complex; • presynaptic membrane; • neuronal cell body; • hippocampal mossy fiber to CA3 synapse; • glutamatergic synapse;
Prosesau biolegol	• neuron apoptotic process; • glutamate receptor signaling pathway; • modulation of chemical synaptic transmission; • cludo ïon; • receptor clustering; • cludo transmembrane rhwng ïonau; • positive regulation of neuron apoptotic process; • regulation of JNK cascade; • ionotropic glutamate receptor signaling pathway; • positive regulation of synaptic transmission; • excitatory postsynaptic potential; • negative regulation of synaptic transmission, glutamatergic; • chemical synaptic transmission; • behavioral fear response; • cellular calcium ion homeostasis; • intracellular protein transport; • neuronal action potential; • synaptic transmission, glutamatergic; • regulation of membrane potential; • GO:1904089 negative regulation of neuron apoptotic process; • regulation of long-term neuronal synaptic plasticity; • regulation of short-term neuronal synaptic plasticity; • inhibitory postsynaptic potential; • regulation of presynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologau
	2898
	n/a
	ENSG00000164418
	n/a
	Q13002
	n/a
	NM_001166247; NM_021956; NM_175768
	n/a
	NP_001159719; NP_068775; NP_786944
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRIK2 yw GRIK2 a elwir hefyd yn Glutamate ionotropic receptor kainate type subunit 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q16.3.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRIK2.

EAA4
GLR6
MRT6
GLUK6
GLUR6
GluK2

Llyfryddiaeth[golygu | golygu cod]

"[Association between glutamate receptor 2 polymorphisms and epilepsy in children]. ". Zhongguo Dang Dai Er Ke Za Zhi. 2016. PMID 27324535.
"Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state. ". J Physiol. 2013. PMID 23713029.
"Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy. ". Ophthalmologica. 2013. PMID 23037145.
"TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease. ". Biochem Biophys Res Commun. 2012. PMID 22771793.
"Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor.". Biochemistry. 2010. PMID 20863077.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] GRIK2 - Cronfa NCBI

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[2]