GRIK1

GRIK1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2ZNS, 2ZNT, 2ZNU, 3FUZ, 3FV1, 3FV2, 3FVG, 3FVK, 3FVN, 3FVO, 4MF3
Dynodwyr
Cyfenwau	GRIK1, EAA3, EEA3, GLR5, GLUR5, GluK1, gluR-5, glutamate ionotropic receptor kainate type subunit 1
Dynodwyr allanol	OMIM: 138245 HomoloGene: 68992 GeneCards: GRIK1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ion channel activity • kainate selective glutamate receptor activity • extracellularly glutamate-gated ion channel activity • ionotropic glutamate receptor activity • ligand-gated ion channel activity • signaling receptor activity • glutamate receptor activity • transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cydrannau o'r gell • integral component of membrane • cell junction • Cellbilen • postsynaptic membrane • integral component of plasma membrane • synapse • bilen • kainate selective glutamate receptor complex • presynaptic membrane Prosesau biolegol • glutamate receptor signaling pathway • central nervous system development • cludo transmembrane rhwng ïonau • regulation of synaptic transmission, glutamatergic • cludo ïon • nervous system development • chemical synaptic transmission • ionotropic glutamate receptor signaling pathway • excitatory postsynaptic potential • synaptic transmission, glutamatergic • modulation of chemical synaptic transmission • regulation of postsynaptic membrane potential Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2897	n/a
Ensembl	ENSG00000171189	n/a
UniProt	P39086	n/a
RefSeq (mRNA)	NM_000830 NM_175611 NM_001320616 NM_001320618 NM_001320621 NM_001320630 NM_001330993 NM_001330994 NM_001393424 NM_001393425 NM_001393426	n/a
RefSeq (protein)	NP_000821 NP_001307545 NP_001307547 NP_001307550 NP_001307559 NP_001317922 NP_001317923 NP_783300	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRIK1 yw GRIK1 a elwir hefyd yn Glutamate ionotropic receptor kainate type subunit 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 21, band 21q21.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRIK1.

• EAA3
• EEA3
• GLR5
• GLUR5
• GluK1
• gluR-5

Llyfryddiaeth

• "Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking. ". Addict Biol. 2016. PMID 25496338.
• "Topiramate's reduction of body mass index in heavy drinkers: lack of moderation by a GRIK1 polymorphism. ". Exp Clin Psychopharmacol. 2014. PMID 24978347.
• "GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink. ". Int J Neuropsychopharmacol. 2014. PMID 24786948.
• "Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. ". Am J Psychiatry. 2014. PMID 24525690.
• "Association study of GRIK1 gene polymorphisms in schizophrenia: case-control and family-based studies.". Hum Psychopharmacol. 2012. PMID 22730074.