GRIA2

GRIA2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2WJW, 2WJX, 2XHD, 3R7X, 3RN8, 3RNN, 3UA8, 5H8S
Dynodwyr
Cyfenwau	GRIA2, GLUR2, GLURB, GluA2, GluR-K2, HBGR2, glutamate ionotropic receptor AMPA type subunit 2, gluR-B, gluR-2, NEDLIB
Dynodwyr allanol	OMIM: 138247 HomoloGene: 20225 GeneCards: GRIA2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • ion channel activity • GO:0001948, GO:0016582 protein binding • ionotropic glutamate receptor activity • extracellularly glutamate-gated ion channel activity • excitatory extracellular ligand-gated ion channel activity • AMPA glutamate receptor activity • amyloid-beta binding • signaling receptor activity Cydrannau o'r gell • integral component of membrane • endocytic vesicle membrane • postsynaptic membrane • endoplasmic reticulum membrane • bilen • Cellbilen • synapse • integral component of plasma membrane • cell junction • Reticwlwm endoplasmig • AMPA glutamate receptor complex • external side of plasma membrane • dendrite • dendritic spine • excitatory synapse • postsynapse • postsynaptic endocytic zone • GO:0097483, GO:0097481 postsynaptic density Prosesau biolegol • cludo ïon • cludo transmembrane rhwng ïonau • ionotropic glutamate receptor signaling pathway • GO:0015915 transport • GO:0072468 signal transduction • chemical synaptic transmission • excitatory postsynaptic potential • synaptic transmission, glutamatergic • regulation of NMDA receptor activity Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2891	n/a
Ensembl	ENSG00000120251	n/a
UniProt	P42262	n/a
RefSeq (mRNA)	NM_000826 NM_001083619 NM_001083620 NM_001379000 NM_001379001	n/a
RefSeq (protein)	NP_000817 NP_001077088 NP_001077089 NP_001365929 NP_001365930	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRIA2 yw GRIA2 a elwir hefyd yn Glutamate receptor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 4, band 4q32.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRIA2.

• GLUR2
• GLURB
• GluA2
• HBGR2
• GluR-K2

Llyfryddiaeth

• "Ca2+ -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma. ". Epilepsia. 2017. PMID 28195308.
• "Structural rearrangement of the intracellular domains during AMPA receptor activation. ". Proc Natl Acad Sci U S A. 2016. PMID 27313205.
• "Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease. ". Neurobiol Aging. 2014. PMID 24679603.
• "Maturation of AMPAR composition and the GABAAR reversal potential in hPSC-derived cortical neurons. ". J Neurosci. 2014. PMID 24623784.
• "A charge-inverting mutation in the "linker" region of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors alters agonist binding and gating kinetics independently of allosteric modulators.". J Biol Chem. 2014. PMID 24550387.