GRB2

GRB2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1AZE, 1BM2, 1BMB, 1CJ1, 1FHS, 1FYR, 1GCQ, 1GFC, 1GFD, 1GHU, 1GRI, 1IO6, 1JYQ, 1JYR, 1JYU, 1QG1, 1TZE, 1X0N, 1ZFP, 2AOA, 2AOB, 2H5K, 2HUW, 2VVK, 2VWF, 2W0Z, 3C7I, 3IMD, 3IMJ, 3IN7, 3IN8, 3KFJ, 3MXC, 3MXY, 3N7Y, 3N84, 3N8M, 3OV1, 3OVE, 3S8L, 3S8N, 3S8O, 2H46, 3WA4, 4P9V, 4P9Z, 5CDW
Dynodwyr
Cyfenwau	GRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
Dynodwyr allanol	OMIM: 108355 HomoloGene: 1576 GeneCards: GRB2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • protein domain specific binding • SH3 domain binding • protein kinase binding • identical protein binding • neurotrophin TRKA receptor binding • protein phosphatase binding • GO:0001948, GO:0016582 protein binding • ephrin receptor binding • insulin receptor substrate binding • epidermal growth factor receptor binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity • phosphoprotein binding • enzyme binding • RNA binding • non-membrane spanning protein tyrosine kinase activity • phosphotyrosine residue binding Cydrannau o'r gell • extracellular exosome • nucleolus • cytoplasm • nucleoplasm • COP9 signalosome • Golgi apparatus • cytosol • cnewyllyn cell • cell-cell junction • bilen • Grb2-EGFR complex • endosome • vesicle membrane • Cellbilen • extrinsic component of cytoplasmic side of plasma membrane • GO:0009327 protein-containing complex • intracellular anatomical structure Prosesau biolegol • T cell costimulation • Fc-gamma receptor signaling pathway involved in phagocytosis • branching involved in labyrinthine layer morphogenesis • MAPK cascade • epidermal growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • GO:1901047 insulin receptor signaling pathway • receptor internalization • cell-cell signaling • axon guidance • positive regulation of reactive oxygen species metabolic process • cellular response to ionizing radiation • Fc-epsilon receptor signaling pathway • GO:0022415 viral process • positive regulation of actin filament polymerization • signal transduction in response to DNA damage • negative regulation of epidermal growth factor receptor signaling pathway • leukocyte migration • regulation of MAPK cascade • anatomical structure formation involved in morphogenesis • GO:0010260 heneiddio • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • phosphatidylinositol-3-phosphate biosynthetic process • protein heterooligomerization • entry of bacterium into host cell • membrane organization • cell migration • cell differentiation • peptidyl-tyrosine autophosphorylation • regulation of cell population proliferation • innate immune response • Ras protein signal transduction • interleukin-15-mediated signaling pathway • positive regulation of protein kinase B signaling • regulation of molecular function • cytokine-mediated signaling pathway • positive regulation of Ras protein signal transduction • neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2885	n/a
Ensembl	ENSG00000177885	n/a
UniProt	P62993	n/a
RefSeq (mRNA)	NM_203506 NM_002086	n/a
RefSeq (protein)	NP_002077 NP_987102	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRB2 yw GRB2 a elwir hefyd yn Growth factor receptor-bound protein 2 a Growth factor receptor bound protein 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 17, band 17q25.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GRB2.

• ASH
• Grb3-3
• MST084
• NCKAP2
• MSTP084
• EGFRBP-GRB2

Llyfryddiaeth

• "Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide. ". Protein Sci. 2016. PMID 26645482.
• "Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. ". Nat Commun. 2015. PMID 26103942.
• "Regions outside of conserved PxxPxR motifs drive the high affinity interaction of GRB2 with SH3 domain ligands. ". Biochim Biophys Acta. 2015. PMID 26079855.
• "Quantitative proteomics reveals the downregulation of GRB2 as a prominent node of F806-targeted cell proliferation network. ". J Proteomics. 2015. PMID 25659534.
• "Overexpression of GRB2 is correlated with lymph node metastasis and poor prognosis in esophageal squamous cell carcinoma.". Int J Clin Exp Pathol. 2014. PMID 25031732.