GRB14

GRB14
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AUG, 2AUH, 4K81
Dynodwyr
Cyfenwau	GRB14, growth factor receptor bound protein 14
Dynodwyr allanol	OMIM: 601524 HomoloGene: 3303 GeneCards: GRB14
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • receptor tyrosine kinase binding • identical protein binding • protein homodimerization activity Cydrannau o'r gell • cytoplasm • cytosol • endosome • Cellbilen • endosome membrane • intracellular membrane-bounded organelle • bilen Prosesau biolegol • positive regulation of signal transduction • leukocyte migration • GO:0072468 signal transduction • GO:1903105 negative regulation of insulin receptor signaling pathway • GO:1901047 insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	2888	n/a
Ensembl	ENSG00000115290	n/a
UniProt	Q14449	n/a
RefSeq (mRNA)	NM_001303422 NM_004490	n/a
RefSeq (protein)	NP_001290351 NP_004481	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GRB14 yw GRB14 a elwir hefyd yn Growth factor receptor bound protein 14 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q24.3.

Llyfryddiaeth

• "Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor. ". J Biochem. 2017. PMID 28130417.
• "High expression of growth factor receptor-bound protein 14 predicts poor prognosis for colorectal cancer patients. ". Biotechnol Lett. 2016. PMID 26965150.
• "Identifying candidate genes for Type 2 Diabetes Mellitus and obesity through gene expression profiling in multiple tissues or cells. ". J Diabetes Res. 2013. PMID 24455749.
• "Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. ". Diabetologia. 2013. PMID 23827965.
• "The insulin resistance Grb14 adaptor protein promotes thyroid cancer ret signaling and progression.". Oncogene. 2012. PMID 22158039.