GOT1

GOT1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	3II0, 3WZF
Dynodwyr
Cyfenwau	GOT1, ASTQTL1, GIG18, cAspAT, cCAT, AST1, glutamic-oxaloacetic transaminase 1
Dynodwyr allanol	OMIM: 138180 HomoloGene: 1571 GeneCards: GOT1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • L-aspartate:2-oxoglutarate aminotransferase activity; • L-cysteine:2-oxoglutarate aminotransferase activity; • transaminase activity; • catalytic activity; • carboxylic acid binding; • L-phenylalanine:2-oxoglutarate aminotransferase activity; • phosphatidylserine decarboxylase activity; • pyridoxal phosphate binding;
Cydrannau o'r gell	• cytoplasm; • axon terminus; • mitocondria; • lysosome; • extracellular exosome; • cnewyllyn cell; • nucleoplasm; • cytosol;
Prosesau biolegol	• Notch signaling pathway; • gluconeogenesis; • dicarboxylic acid metabolic process; • aspartate metabolic process; • aspartate catabolic process; • cellular amino acid metabolic process; • response to glucocorticoid; • cellular amino acid biosynthetic process; • biosynthesis; • 2-oxoglutarate metabolic process; • oxaloacetate metabolic process; • glutamate catabolic process to 2-oxoglutarate; • aspartate biosynthetic process; • fatty acid homeostasis; • cellular response to insulin stimulus; • glutamate catabolic process to aspartate; • glutamate metabolic process; • glycerol biosynthetic process; • response to carbohydrate; • positive regulation of transforming growth factor beta receptor signaling pathway; • negative regulation of collagen biosynthetic process; • response to immobilization stress; • response to cadmium ion; • negative regulation of cytosolic calcium ion concentration; • negative regulation of mitochondrial depolarization; • transdifferentiation; • cellular response to mechanical stimulus; • response to transition metal nanoparticle;
	Sources:Amigo / QuickGO
Orthologau
	2805
	n/a
	ENSG00000120053
	n/a
	P17174
	n/a
	NM_002079
	n/a
	NP_002070
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn GOT1 yw GOT1 a elwir hefyd yn Glutamic-oxaloacetic transaminase 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 10, band 10q24.2.^[2]

Cyfystyron[golygu | golygu cod]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn GOT1.

AST1
cCAT
GIG18
cAspAT
ASTQTL1

Llyfryddiaeth[golygu | golygu cod]

"GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. ". Cancer Lett. 2017. PMID 28455244.
"Stratified aspartate aminotransferase-to-platelet ratio index accurately predicts survival in hepatocellular carcinoma patients undergoing curative liver resection. ". Tumour Biol. 2017. PMID 28351330.
"Association of aspartate aminotransferase with mortality in hemodialysis patients. ". Nephrol Dial Transplant. 2016. PMID 26333544.
"Expression, purification and preliminary crystallographic studies of human glutamate oxaloacetate transaminase 1 (GOT1). ". Protein Expr Purif. 2015. PMID 26003525.
"GOT1/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma.". Oncotarget. 2015. PMID 25595905.

Cyfeiriadau[golygu | golygu cod]

[1] "Human PubMed Reference:".

[2] GOT1 - Cronfa NCBI

[1]

[2]